The role of Vi antigen in human immunity against typhoid fever has been debated for decades. Circumstantial evidence indicates that Vi antigen may play a role in pathogenicity and immunity. A Vi preparation was isolated from Salmonella typhosa, the causative organism in human typhoid fever, by a mild precipitation method. It was significantly more potent in animal studies than preparations from...

the purpose of this study was to assess the effect of preventive immunization on the incidence of allergies in poland.18617 (53.8% female, 24.2% 6-7 years old, 25.4% 13-14 years old, 50.4% 20–44 years old) were selected by stratified cluster sampling method in 8 cities and 1 rural area. 4783 of whom underwent objective outpatient screening assessments. study subjects were evaluated for any asso...

Ninety-seven Nigerian children under 5 years of age had typhoid or paratyphoid fever proved by blood culture. The presented with fever, anaemia, gastrointestinal or neurological disturbances, and typhoid and paratyphoid appeared clinically indistinguishible. In this holoendemic malarial area, malaria was the most important differential diagnosis, and may have contributed to the concomitant anae...

A consideration of the Edinburgh notification statistics tends to show that the season of greatest prevalence of typhoid fever is during the three autumnal months?September, October, and November. This coincides generally with the statistics of other places in the United Kingdom, and also with Buchan and Mitchell's curve, based on the mortality returns of London. In fact, typhoid fever remains ...

Objective The diagnosis of typhoid fever is made by growth of the causative microorganism from culture of bone marrow aspirate or blood which is time dependent. In a busy ED like ours, typhoid fever is a frequent presentation. There is need for a rapid and reliable test made available at the bed side, to detect typhoid infections. The sensitivity and specificity of Enterocheck WB, a card test t...

We report the coverage, safety, and logistics of a school-based typhoid fever immunization campaign that took place in Hue City, central Vietnam; a typhoid fever endemic area. A clusterrandomized evaluation-blinded controlled trial was designed where 68 schools (cluster) were randomly allocated the single dose Vi polysaccharide vaccine (Typherix®) or the active control hepatitis A vaccine (Havr...

mycetin on typhoid were published about two years ago (Woodward et al., 1948), but it is only since last year that this new antibiotic has become available in India. A fair number of reports have appeared since in the literature in India and abroad which show that Chloromycetin has a specific action in typhoid fever. Typhoid fevers, apart from occasional outbreaks, have become a rarity in Weste...

INTRODUCTION There is an urgent need for affordable point-of-care diagnostics for the differentiation of febrile illnesses and the confirmation of typhoid in endemic countries. METHODOLOGY Blood samples were collected from febrile patients with clinical suspicion of typhoid and screened for typhoid fever using the Widal and Typhi Dri Dot tests, while stool and blood samples were screened for ...

In this issue of Clinical Infectious Diseases, 2 papers shed important light on the problem of typhoid fever in Sub-Saharan Africa and stimulate reflection on the challenges raised by the syndrome of fever in low-resource settings. Neil et al [1] report the investigation of an increase in intestinal perforations from rural western Uganda. By improving the clinical microbiology services availabl...