BACKGROUND Bariatric surgery is able to improve glucose and lipid metabolism, and cardiovascular function in morbid obesity. Aim of this study was to compare the long-term effects of malabsorptive (biliary pancreatic diversion, BPD), and restrictive (laparoscopic gastric banding, LAGB) procedures on metabolic and cardiovascular parameters, as well as on metabolic syndrome in morbidly obese pati...

Determining the regulation of metabolic networks at genome scale is a hard task. It has been hypothesized that biochemical pathways and metabolic networks might have undergone an evolutionary process of optimization with respect to several criteria over time. In this contribution, a multi-criteria approach has been used to optimize parameters for the allosteric regulation of enzymes in a model ...

background: severe metabolic acidosis occurs during orthotopic liver transplantation (olt) particularly during the anhepatic phase. although nahco3 is considered as the current standard therapy, there are numerous adverse effects. the aim of this study was to determine whether the restricted use of normal saline during anesthesia could reduce the need for nahco3. methods: in this study we enrol...

Spatial control over enzyme organization presents a promising posttranslational strategy for improving metabolic flux. Directly tethering enzyme polypeptides has had inconsistent success. Use of a separate scaffold molecule, built from modular protein-protein interaction domains, provides designable control over enzyme assembly parameters, including stoichiometry, as well as providing scalabili...

OBJECTIVE SSRIs are some of the most widely prescribed medications in the world. In addition to their effectiveness, SSRIs were reported to be associated with the side effects of weight gain, sexual dysfunction, drug interactions, extrapyramidal symptoms and discontinuation symptoms. However, the effects of SSRIs on metabolic parameters are poorly understood. METHODS This study aims to descri...