BACKGROUND Phthalates are widely used chemicals, and human exposure is extensive. Recent studies have indicated that phthalates may have thyroid-disrupting properties. OBJECTIVE We aimed to assess concentrations of phthalate metabolites in urine samples from Danish children and to investigate the associations with thyroid function, insulin-like growth factor I (IGF-I), and growth. METHODS I...

AIMS This study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis. METHODS Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analy...

Metabolomics is a promising tool to gain new insights into early metabolic alterations preceding the development of hypertension in humans. We therefore aimed to identify metabolites associated with incident hypertension using measured data of serum metabolites of the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam study. Targeted metabolic profiling was conducted on...

conclusions serum p and ipth levels were independently associated with et-1 and those may play a role in development of endothelial dysfunction in chronic kidney disease. patients and methods in this cross-sectional study, 46 chronic stable hd patients were selected from nephrology departments of tabriz university of medical sciences affiliated hospitals and classified based on phosphorus (p), ...

Serum concentrations of primidone and its metabolites-phenobarbitone and phenylethylmalonamide-were measured in 40 epileptic patients receiving treatment with primidone alone or primidone plus phenytoin. Serum phenobarbitone concentrations were also measured in 100 patients receiving phenobarbitone, alone or with phenytoin showed raised serum phenobarbitone concentrations. Phenytoin also caused...

Vitamin D3 (1) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin (6a) and 4β,25-dihydroxyvitamin (6b) are both produced from 25-hydroxyvitamin (2) CYP3A4. However, 6b detectable serum, whereas 6a not. We hypothesized that reason for this a difference susceptibility to CYP24A1-mediated metabolism. Here, ...

1H NMR is used to detect alterations in metabolites and their linkage to metabolic processes in a number of pathological conditions including breast cancer. Inositol 1, 4, 5 trisphosphate (IP3R) receptor is an intracellular calcium channel known to regulate metabolism and cellular bioenergetics. Its expression is up regulated in a number of cancers. However, its linkage to metabolism in disease...

OBJECTIVE Liquid chromatography/mass spectrometry (LC/MS)-based comprehensive analysis of metabolic profiles with metabolomics approach has potential diagnostic and predictive implications. However, no metabolomics data have been reported in adult-onset Still's disease (AOSD). This study investigated the metabolomic profiles in AOSD patients and examined their association with clinical characte...

and Invited Presentation: Dec 2013 American Association for Cancer Research (AACR)The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, Atlanta, GA.“Vitamin D and prostate Cancer in African-American Men” Abstract and Poster presentation: November 2015 Steroid Research Congress Chicago. “Vitamin D metabolites in prostate tissue and serum from African...