Cancer cell metabolism has received increasing attention. Despite a boost in the application of clinical metabolic profiling (CMP) in cancer patients, a meta-analysis has not been performed. The primary goal of this study was to assess whether public accessibility of metabolomics data and identification and reporting of metabolites were sufficient to assess which metabolites were consistently a...

SUMMARY The complex, rapidly evolving field of computational metabolomics calls for collaborative infrastructures where the large volume of new algorithms for data pre-processing, statistical analysis and annotation can be readily integrated whatever the language, evaluated on reference datasets and chained to build ad hoc workflows for users. We have developed Workflow4Metabolomics (W4M), the ...

OVERVIEW Type 2 (or non insulin dependent) diabetes is one of the most common diseases in the western world, with over 150 million afflicted worldwide. Currently, none of the available animal models used to aid research into diagnostics and new anti-diabetic drugs reflect all disease aspects in man. More detailed model characterization compared to man is therefore essential to help make better ...

Metabolomics involves the large-scale simultaneous (mul-tiparallel) qualitative and quantitative analysis of small metabolites present in biological samples from either human , animal or plant origins. As such, metabolomics is highly complementary to other tools including genom-ics, transcriptomics and proteomics. Especially sensitive mass spectrometry approaches have evolved as valuable techni...

Metabolomics is a technology that generates large amounts of data and contributes to obtaining wide integral explanations the biochemical state living organism. Plants are continuously affected by abiotic stresses such as water scarcity, high temperatures salinity, metabolomics has potential for elucidating response-to-stress mechanisms develop resistance strategies in cultivars. This review de...

Metabolic profiling can be used to assess the changes in biochemical profiles of soil communities living in contaminated sites. The term "community metabolomics" is proposed for the application of metabolomics techniques to the study of the entire community of a soil sample. The authors anticipate the present study to be a starting point for the use of this technique to assess how communities r...

Following similar global efforts to exchange genomic and other biomedical data, global databases in metabolomics have now been established. MetaboLights, the first general purpose, publically available, cross-species, cross-application database in metabolomics, has become the fastest growing data repository at the European Bioinformatics Institute in terms of data volume. Here we present the au...

Metabolomics is the “omics” that studies the whole metabolome. It has a wide range of applications, inter alia chemotaxonomy, environmental influences, agriculture, etc. Here we review the application of metabolomics in natural product research. The importance of physicochemical properties to drug delivery are discussed in relation to turning metabolomic studies towards drug discovery. We belie...

Neuropathic pain is a debilitating condition for which the development of effective treatments has been limited by an incomplete understanding of its chemical basis. We show by using untargeted metabolomics that sphingomyelin-ceramide metabolism is altered in the dorsal horn of rats with neuropathic pain and that the upregulated, endogenous metabolite N,N-dimethylsphingosine induces mechanical ...

Along with genes and proteins, metabolites play important roles in sustaining life. Their functions include "primary" functions in metabolism and energy storage, as well as "secondary" functions in cell-to-cell signaling, metal acquisition, and virulence. There remains much to be learned about the in vivo roles of metabolites. Approaches that accelerate measurement of metabolite levels directly...