Asbestos exhibits many properties of classical tumor pro moters. These characteristics include the ability to stimulate proliferation and inhibit normal differentiation of cells. In organ cultures of trachea, crocidolite and amosite asbestos stimulate squamous metaplasia, a pathological process in which a rapidly proliferating squamous epithelium replaces the normal epithe lium. We hypothesized...

Barrett's oesophagus is a premalignant metaplastic condition that predisposes patients to the development of oesophageal adenocarcinoma. However, only a minor fraction of Barrett's oesophagus patients progress to adenocarcinoma and it is thus essential to determine bio-molecular markers that can predict the progression of this condition. Telomere dysfunction is considered to drive clonal evolut...

Columnar epithelium-lined oesophagus (CELO) is an acquired disorder associated with a high incidence of cancer. CELO consists of three histological types of epithelium: gastric-fundic, junctional, and specialised columnar, the last resembling intestinal metaplasia of the stomach. In a previous study of CELO an incompletely differentiated variant of intestinal metaplasia secreting sulphomucins (...

The acquisition of genetic/epigenetic mutations in long-lived gastrointestinal stem cells leads to the development of cancer, as well as precancerous lesions such as metaplasia and dysplasia. In the proximal stomach corpus, this model of progression from stem cells has been supported by studies in mice and human beings, showing abundant proliferation in the isthmus and clonal expansion of mutat...

INTRODUCTION worldwide, stomach cancer is the fifth most frequent cancer, with 952 000 new cases diagnosed in 2012. Ecuador currently holds the 15th place of countries with the highest incidence of stomach cancer for both sexes. OBJECTIVES the objective of this study was to evaluate risk and protective factors for gastric cancer/metaplasia. METHODS a hospital-based case-control study was co...

Background: Osseous metaplasia occurring within the gastrointestinal tract is a rare phenomenon. Only a few of cases have been documented that osseous metaplasia can occur in colorectal polyps, although its underlying pathogenesis has not yet been elucidated. Methods: Two cases of osseous metaplasia within inflammatory and adenomatous polyps of colon, respectively. The clinical and histological...

Duodenal ulcers are associated with gastric metaplasia in the duodenum, both at the ulcer margin and at more distant sites in the duodenal bulb. pS2 and human spasmolytic polypeptide (hSP) are secretory peptides expressed in gastric epithelial cells and in gastric metaplasia. As these peptides may be important in ulcer healing, this study investigated the possibility that the expression of pS2 ...

background: helicobacter pylori ( h. pylori ) is the cause of most cases of peptic ulcers and gastric cancers and cause some of the most important cause of stomach cancer and lymphoma. the objective of this study was to evaluate the time trend of helicobacter pylori prevalence and presence of intestinal metaplasia over the period of 7 years in gastritis iranian patients. materials and methods: ...

•We present a case of multiple mucinous metaplasia and neoplasia of cervix, endometrium, fallopian tube, ovary, and mesenterium with external urethral meatus neoplasm.•Immunohistochemistry showed almost same pattern in each neoplasms.•PCR-direct sequencing showed no existence of both KRAS and GNAS mutations.•This report suggests a possibility of synchronous mucinous metaplasia and neoplasia "be...

Background: Smoking is hazardous to almost any organ in the body and has a harmful effect on gastric mucosa. Objective: The main goal of this study was evaluate synergistic smoking H. pylori infection mucosal among dyspeptic Egyptian patients. Patients Methods: A cross-sectional conducted 240 consecutive patients with dyspepsia who underwent upper endoscopy histopathological examination biopsie...