We have used microcell fusion-mediated chromosomal transfer to introduce normal human chromosomes into highly metastatic rodent prostatic cancer cells to map the location of a metastasis suppressor gene(s). Using this approach, several chromosomal regions have been identified that harbor such metastatic suppressor genes, including human chromosome 11 between p11.2-13 (T. Ichikawa et al., Cancer...

Although prevalence estimates are imprecise, growing numbers of women in the United States are living longer with metastatic breast cancer, attributable at least in part to the availability of effective targeted therapies. Women living with metastatic disease are understudied, however, and substantial heterogeneity exists in both the clinical characteristics of metastatic tumors and the physica...

A patient diagnosed with advanced lung cancer developed severe dyspnea after chemotherapy. Metastatic tumor completely obstructing the lower trachea was revealed by bronchoscopy. Emergent surgery required but it difficult to perform open tracheal and maintain sufficient ventilation intubation because of location size tumor. After consultation an esthesiologist, respiratory physician cardiothora...

Advanced ovarian cancers are highly metastatic due to frequent peritoneal dissemination, resulting in dismal prognosis. Here we report the functions of cancer-derived extracellular vesicles (EVs), which are emerging as important mediators of tumour metastasis. The EVs from highly metastatic cells strongly induce metastatic behaviour in moderately metastatic tumours. Notably, the cancer EVs effi...

Male breast cancer is uncommon, accounting for less than 1% of all breast cancers. Carcinoma metastatic to the male breast is also unusual, with metastatic prostatic carcinoma being among the most common primary sites from which such tumours derive. Metastatic prostatic cancer and primary breast cancer may be histologically indistinguishable without immunohistochemistry because both often infil...

Despite all the blood-based biomarkers used to monitor prostate cancer patients, prostate cancer remains as the second common cause of cancer mortality in men in the United States. This is largely due to a lack of understanding of the molecular pathways that are responsible for the aggressive forms of prostate cancers, the castrate-resistant prostate cancer and the metastatic prostate cancer. C...

subcutaneous metastatic nodules are an uncommon first sign of underlying cancer. cutaneous metastasis occurs in 0.8% to 4% of all cancer patients and less than 5% in those with lung cancer. these metastases are usually single or multiple painless nodules that may be mobile or fixed. cutaneous metastases from the lung are not very common and indicate a worse prognosis. the limited literature on ...

A computed tomography scan of the chest in an 83-year-old male patient with a history metastatic squamous cell lung cancer revealed mass localized to left ventricle. Subsequent imaging this be incidental cardiac fibroma.

abstract carcinoma of the cervix is a common neoplasm and accounts for a considerable number of cervical diseases that lead to death in developing countries. in these countries early detection and improved methods of treatment have resulted in comparatively better control of the cancer and long survival however, invasive and metastatic disease still occurs. the authors present the case report o...

Quantitative activity measurements of 18F-FDG PET/CT accumulation in visceral adipose tissue epithelial ovarian cancer and colorectal the abdominal cavity pelvis with metastatic lesions omentum lymph nodes baseline follow-up patients are presented