نتایج جستجو برای: methylenedioxymethamphetamine

تعداد نتایج: 1065  

Journal: :Neuroscience 2002
L Matuszewich M E Filon D A Finn B K Yamamoto

(+/-)3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is an increasingly popular drug of abuse that acts as a neurotoxin to forebrain serotonin neurons. The neurochemical effects of the serotonin depletion following high doses of MDMA were investigated in response to acute immobilization stress. Male rats were treated with a neurotoxic dosing regimen of MDMA (10 mg/kg, i.p. every 2 h for fou...

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Werner Klingler James J A Heffron Karin Jurkat-Rott Grainne O'sullivan Andreas Alt Friedrich Schlesinger Johannes Bufler Frank Lehmann-Horn

Adverse 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) effects are usually ascribed to neurotransmitter release in the central nervous system. Since clinical features such as fasciculations, muscle cramps, rapidly progressing hyperthermia, hyperkalemia, and rhabdomyolysis point to the skeletal muscle as additional target, we studied the effects of MDMA on native and cultured skeletal muscle....

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