The aim of this study is to evaluate the specificities of the irradiation of drugs in frozen aqueous solution. The structures of the degradation products were determined to gain insight into the radiolysis mechanisms occurring in frozen aqueous solutions. Metoclopramide hydrochloride and metoprolol tartrate were chosen as models. The frozen solutions were irradiated at dry ice temperature by hi...

OBJECTIVE To compare the results of Tropisetron, Metoclopramide and placebo on postoperative nausea and vomiting in patients undergoing minilaparotomy cholecystectomy. SETTING Patients operated for minilaparotomy cholecystectomy in two private hospitals in Karachi. SUBJECTS Fifty consecutive patients of all ages and both sex who had simple cholelithiasis and underwent minilaparotomy cholecy...

The serotonin (5HT3) antagonist ondansetron was compared in a randomised study with metoclopramide and dexamethasone for the prevention of chemotherapy induced emesis. Thirty children aged 1-15 years with acute lymphoblastic leukaemia received 'intensification modules' according to the MRC United Kingdom acute lymphoblastic leukaemia regimen UKALL XI. This contains the moderately emetogenic dru...

A 26-year-old Malaysian woman (childbearing age) attended a private primary care clinic with known case of gastroesophageal reflux disease (GERD) and complained persistent nausea few episodes vomiting. She had no drug allergy, surgical history, hospitalization in the last two years, was non-smoker, history or alcohol abuse. The patient prescribed Tab metoclopramide 10 mg TDS ranitidine 150 BD f...

SULFHEMOGLOBIN is a rare cause of cyanosis that is usually drug induced. The effects of sulfhemoglobin on pulse oximetry have not been reported widely. We present the case of a 48-yr-old woman who was scheduled to undergo palliative surgery. Before anesthesia, she had an oxygen saturation, measured by pulse oximetry (SpO2), of 85%. This apparent desaturation subsequently was discovered to be th...

in psychopathology, which worsened after a three-day washout period and became similar to that seen before metoclopramide treatment. The patient was then treated with the classical neuroleptic haloperidol. At a dose of 45 mg/day the same extrapyramidal syndrome re-emerged and was completely responsive to trihexyphenidyl 2 mg by mouth three times daily. After haloperidol dosage was increased to ...

Ranitidine and metoclopramide are routinely given intravenously before surgical procedures that involve spinal or general anesthesia. Recently, another institution contacted our institution to request stability data to support the practice of routinely mixing ranitidine 50 mg and metoclopramide 10 mg in a 50-mL minibag of normal saline (0.9% sodium chloride) for IV administration before cesarea...

STUDY OBJECTIVE We compare prochlorperazine 10 mg intravenously versus metoclopramide 20 mg intravenously for the emergency department (ED) treatment of acute migraine. METHODS This was a randomized, double-blind, clinical trial comparing 2 parenteral dopamine antagonists. Both drugs were administered during 15 minutes with 25 mg intravenous diphenhydramine. Pain scores on a numeric rating sc...

BACKGROUND AND PURPOSE Pneumonia is a major cause of mortality and morbidity in patients with stroke fed via nasogastric tubes and may be because of vomiting and gastro-oesophageal regurgitation. The aim of the study was to assess whether regular treatment with metoclopramide, a D2-receptor antagonist with antiemetic and gastric prokinetic actions, could reduce the rate of aspiration and pneumo...