In the central nervous system, magnesium ion (Mg2+) acts as an endogenous modulator of N-methyl-D-aspartate (NMDA)-coupled calcium channels, and may play a major role in the pathomechanisms of ischemic brain damage. In the present study, we investigated the effects of magnesium chloride (MgCl2, 2.5, 5.0 or 7.5 mmol/kg), either alone or in combination with diazepam (DZ), on ischemia-induced hipp...

hydroalcoholic extract of pycnocycla spinosa is a relaxant of rat ileum and inhibits diarrhea in mice. as p. spinosa extract has spasmolytic activity on ileum, it could also affect other smooth muscles like bladder. therefore, the aim of this study was to determine the effect of p. spinosa extract on rat bladder contraction. in an in vitro study, the effects of p. spinosa extract, nifedipine an...

The efficacy of acetylcholine muscarinic M2 receptor-G protein coupling was investigated in Alzheimer's disease and control neocortical membranes by measuring the effects of MgCl2 and 5'-guanylylimidodiphosphate (Gpp[NH]p) on high-affinity [3H]oxotremorine-M ([3H]OXO-M) binding. MgCl2 gave similar enhancements of [3H]OXO-M binding in Alzheimer's disease and control occipital cortex. In contrast...

where E0, F, n, aMn+ and aM are a standard decomposition potential, Faraday constant, an electron transfer number, and the activity of an ion M and a product M, respectively. We were interested in the reason of such a stabilization of multivalent cations. Molecular dynamics (MD) simulations give information about the microscopic structure in real space, while diffractional methods give us struc...

1. Adenine nucleotide exchange-transport was reconstituted in vesicles prepared from phospholipids and protein fractions derived from bovine heart submitochondrial particles. The transport, which was specific for ATP and ADP was measured either as ADP/ADP, ATP/ATP, or ADP/ATP exchange. The highest specific activity (370 nanomoles of ADP/ADP exchange/min/mg of protein at room temperature) was ob...

Abstract Metal-free porous biochars are popularly utilized as catalysts for peroxydisulfate (PDS) activation. The enhancement effect of PDS activation fabricated by employing both hard template and alkali metal activating agent has not been explored completely. In addition, the role inherent carbon defect in clearly elucidated. Hence, a series carbonaceous were using sole (KCl), (Na 2 S O 3 ) o...

Hen oviduct chromatin was digested with DNase II and separated into two fractions. The MgCl2 insoluble chromatin fraction (43% of the total DNA) was enriched in nucleosome-like particles, which sedimented at 11 S and contained 185 base pairs of DNA. The MgCl2 soluble chromatin fraction (5% of the total DNA) was characterized by 5 S and 14 S peaks in sucrose gradients; Estrogen receptors in the ...

behaviors of stress corrosion cracking (scc)in martensitic stainless steel(aisi 420) and low carbon austenitic stainless steel (aisi 316l) have been compared under different conditions of temperature, environment (mgcl2), and strain rate. the results show that decreasing strain rate has detrimental effect on mechanical properties of both steels, including their strength and ductility. fractogra...