As one of the complications of diabetes, liver injury results in significant hazards. Therefore, accurately diagnosing diabetes-induced liver injury beforehand is crucial for the warning and treatment of hepatic diseases. Diabetes-induced liver injury can cause changes in the microstructure and morphology of liver tissue, leading to changes in the hydrophilic and hydrophobic domains in the endo...

Time-restricted feeding (TRF) can reduce adiposity and lessen the co-morbidities of obesity. Mice consuming obesogenic high-fat (HF) diets develop insulin resistance hepatic steatosis, but have elevated indices long-chain polyunsaturated fatty acids (LCPUFA) that may be beneficial. While TRF impacts lipid metabolism, scant data exist regarding impact upon lipidomic composition tissues. We (1) t...

Akkermansia muciniphila (A. muciniphila) play an important in ameliorating obesity but is not allowed for direct consumption most countries. To date, microbiota-directed foods selectively promote the targeted human gut microbes, providing a strategy A. enhancement. Multiple studies have indicated potential regulation of polyphenol on muciniphila. Therefore, screening based ...

Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4). Materials and Methods: The acute liver injury model was produced by CCl4 at 10 ml/kg body weight in 24-...

Synthetic pyrethroid insecticides have been widely used for years to prevent harmful effects of insects and control disease vectors. In this study, the resveratrol against potential toxicity permethrin, an effective derivative, on fetus were investigated. Accordingly, Wistar female rats divided into four groups as Control, Sham, Permethrin, Permethrin + Resveratrol. Lung, liver, kidney small in...

Although metabolic syndrome (MS) and systemic lupus erythematosus (SLE) are often associated, a common link has not been identified. Using the BWF1 mouse, which develops MS and SLE, we sought a molecular connection to explain the prevalence of these two diseases in the same individuals. We determined SLE- markers (plasma anti-ds-DNA antibodies, splenic regulatory T cells (Tregs) and cytokines, ...

Mancozeb, a fungicide of a manganese-zinc ethylenebisdithio-carbamate (EBDC), was administered by gavage at doses of 200, 400, 600 and 800 mg/kg/day to female virgin mice for 30 days. The mice were autopsied on 31st day. Mice were also treated with similar doses for a period of 30 days and the treatment was withdrawn for a further period of 30 days for reversible study. The mice were autopsied...

BACKGROUND Although many factors and molecules that are closely associated with non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) have been reported, the role of endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) in the pathogenesis of NAFLD/NASH remains unclear. We therefore investigated the role of eNOS-derived NO in NAFLD pathogenesis using system...

Loss of skeletal muscle mass and function (cachexia) is severe in patients with colorectal liver metastases because of the large increase in resting energy expenditure but remains understudied because of a lack of suitable preclinical models. Our aim was to characterize a novel preclinical model of cachexia in colorectal liver metastases. We tested the hypothesis that mice with colorectal liver...

Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. inhibits precursors of formation, xanthine, and hypoxanthine. However, consumption drugs cause side effects on liver. The aim research was determine effect allopurinol induction liver histopathology male mice (Mus musculus) DDY strain. method this an experimental design post-test...