Our hypothesis tested the efficacy and safety of a mucoadhesive oral gel formulation of Brazilian propolis extract compared to miconazole oral gel for the treatment of denture stomatitis due to Candida spp. infection in older adults. Forty patients were randomly allocated in a noninferiority clinical trial into two groups. The control group (MIC) received 20 mg/g miconazole oral gel and the stu...

BACKGROUND Topical antimicrobial therapy is increasingly important in the treatment of canine pyoderma as the incidence of multidrug resistance has risen. However, little information is reported on the persistence of activity of topical antimicrobial products. OBJECTIVE To determine the residual antibacterial activity of canine hairs treated with antimicrobial sprays. ANIMALS Twelve private...

Objective: The study aimed to solubilization of imidazole drugs of interest; ketoconazole (KT) and miconazole nitrate (MN), for enhancement of the water solubility, the dissolution properties and the antimycotic activity of these drugs. Method: Different solid dispersion methods were used to prepare various dispersion systems of KT and MN using polyethylene glycol 4000 (PEG 4000), polyethylene ...

Urtica dioica or stinging nettle is traditionally used as an herbal medicine in Western Asia. The current study represents the investigation of antimicrobial activity of U. dioica from nine crude extracts that were prepared using different organic solvents, obtained from two extraction methods: the Soxhlet extractor (Method I), which included the use of four solvents with ethyl acetate and hexa...

background and purpose: otomycosis is an acute, subacute or chronic fungal infection of the pinna, the external auditory meatus and the ear canal caused mainly by several species of saprophytic fungi. lamisil (terbinafine) is an allylamine antifungal agent, that is used both in the topical and oral administration for the treatment of dermatophytosis, cutaneous candidiasis, and the pityriasis ve...

We describe a patient in whom phenytoin toxicity developed soon after treatment with parenteral miconazole. A 51 year old man was admitted for treatment of recurrent severe haemoptysis associated with pulmonary aspergillosis. He was in chronic respiratory failure. He was a non-smoker. Biochemical 'indices of liver function were normal. There was a past history of asthma and also of epilepsy for...