RATIONALE The statement is worded this way to remind the practitioner to use both GFR and albuminuria in order to assess progression and is consistent with the definition offered in Chapter 1 regarding definitions of CKD which include both parameters. There is increasing evidence which supports that both parameters are valuable. Lower GFR and greater albuminuria are both associated with an incr...

Chronic inflammation, atherosclerosis, tubulointerstitial fibrosis, and vascular damage play a crucial role in the progression of chronic kidney disease (CKD) patients with type 2 diabetes mellitus (DM). However, specific biomarkers that can determine diabetic disease, including minimal albuminuria, remain undefined.
 The present study aimed to markers inflammation as indicators CKD DM.&#x...

Abstract Background Nonsteroidal, selective mineralocorticoid receptor antagonists (MRAs) have been shown to reduce cardiovascular events among patients with diabetic nephropathy, a clinical syndrome characterized by persistent albuminuria. However, prior reports suggested substantial underuse of MRAs eligible patients. In real-life, it is unknown how many urinary excretion albumin measured, an...

background: in 30 to 40% of patients with type 2 diabetes mellitus (t2dm) nephropathy is developed. the aim of the present study was to find the synergistic effect of two polymorphisms of methylenetetrahydrofolate reductase (mthfr) c677t and angiotensin converting enzyme insertion/ deletion (ace i/d) polymorphism on the risk of diabetic nephropathy and its progression. methods:   in a case-cont...

BACKGROUND Given the increasing costs and poor outcomes of end-stage renal disease (ESRD), we sought to identify risk factors for ESRD in people with preserved estimated glomerular filtration rate (eGFR), with or without albuminuria, who were at high risk of ESRD. METHODS This cohort study included participants in the National Kidney Foundation's Kidney Early Evaluation Program (KEEP) with eG...

BACKGROUND Diabetes is the main cause of ESRD, and albuminuria is a major determinant of adverse renal outcome. Likewise, albuminuria is an intermediate risk factor of chronic kidney disease (CKD) progression in diabetic patients. Our aim was to compare the rate of renal decline in diabetic and non-diabetic CKD patients (GFR < 50 ml/min) with comparable levels of albuminuria. METHODS In this ...

OBJECTIVE To examine the relationship between albuminuria, inflammation, and disability in older adults with diabetes. RESEARCH DESIGN AND METHODS Data were from 1,729 adults (≥ 60 years) with diabetes in the National Health and Nutrition Examination Survey, 1999-2008. Disability in activities of daily living (ADL), instrumental activities of daily living (IADL), leisure and social activities...

Background—Cardiovascular disease (CVD) is now a leading cause of death in HIV-infected persons; however, risk markers for CVD are ill defined in this population. We examined the association between longitudinal measures of kidney function and albuminuria with risk of atherosclerotic CVD and heart failure in a contemporary cohort of HIV-infected individuals. Methods and Results—We followed a na...

EXPERIMENTS ARE DESCRIBED WHICH SHOW THAT: 1. Transient albuminuria follows the infusion of small doses of adrenalin into rabbits, if prolonged over several minutes. 2. Agents causing renal vasoconstriction also cause transient albuminuria in anesthetized, eviscerated dogs. 3. Cats eliminate albumin after having been frightened or enraged. 4. The drug ephedrine, which commonly causes renal vaso...

BACKGROUND AND OBJECTIVES Obesity has been associated with kidney disease in adults. This study was designed to evaluate the association of obesity with an early marker of kidney disease, albuminuria, among young adults. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Urinalysis (n = 9371), albumin-to-creatinine ratio (n = 4463), and body mass index (kg/m2) were measured in the Add Health Wave ...