Obstructive sleep apnea (OSA) causes intermittent nocturnal hypoxemia and is associated with obesity, diabetes, inflammation, endothelial dysfunction, and hypertension, possibly leading to microand macro-vascular disease. OSA has been associated with higher risk of clinical cardiovascular disease (CVD) independent of traditional risk factors and severity of atherosclerosis. Microvascular diseas...

PURPOSE To explore the relationship between chronic kidney disease and diabetic retinopathy in a representative population of Korean diabetic adults. METHODS We analyzed data from the Korea National Health and Nutrition Examination Surveys (2008-2010). A total of 15,409 individuals (weighted frequency, 32,168,636) aged 19 and over who completed ophthalmologic and renal functional examinations...

Corresponding author: Bo Kyung Koo http://orcid.org/0000-0002-6489-2656 Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Korea E-mail: [email protected] The Diabetes Control and Complications Trial (DCCT) confirmed that intensive gluco...

AIMS Few representative population-based data are available regarding glycaemic and HbA1c thresholds for detecting diabetic retinopathy (DR) in Asia. We investigated the association between DR and fasting plasma glucose (FPG) and HbA1c levels among Korean adults. METHODS Using data from the Korea National Health and Nutrition Examination Survey (2011), a total of 5212 adults (≥19 years old) w...

With Ventricular Tachyarrhythmias and Normal Coronary Arteriograms To the Editor: Ouyang et al1 report on 4 patients with recurrent exerciseinduced syncope attributable to fast ventricular tachycardia, aneurysms in the inferior-lateral wall of the left ventricle, and a peculiar subepicardial arrhythmogenic substrate. The authors speculate that this presentation may constitute a distinct clinica...

A rare case of polyangiitis overlap syndrome is described. The patient was a 25-year-old man who had palpable purpura on his legs which showed leukocytoclastic vasculitis, and polyarteritis nodosa. Superior mesenteric arteriography showed microaneurysms in jejunal branches with focal segmental necrotizing arteritis of small and medium sized muscular arteries in the jejunum. Deposits of IgA and ...

AIM To assess the performance of automated disease detection in diabetic retinopathy screening using two field mydriatic photography. METHODS Images from 8,271 sequential patient screening episodes from a South London diabetic retinopathy screening service were processed by the Medalytix iGrading™ automated grading system. For each screening episode macular-centred and disc-centred images of ...

Diabetic retinopathy (DR) is a progressive disease which is the most common cause of blindness and early detection of this disease can limit vision loss. Retinal image grading is crucial for the prevention of visual loss but it is also a time consuming task. The Micro-aneurysm (MA) is the first sign of DR. The automatic detection of Microaneurysms (MAs) is an important and challenging research ...

OBJECTIVE The clinical and pathological characteristics of 10 cases of cerebral amyloid angiopathy (CAA)-related cerebral lobar hemorrhage (CLH) that was diagnosed at autopsy were investigated to facilitate the diagnosis of this condition. METHODS The clinical characteristics of 10 cases of CAA-related CLH were retrospectively reviewed, and a neuropathological examination was performed on aut...

Retinal microaneurysms (MAs) are the earliest clinically observable lesions of diabetic retinopathy. Reliable automated MAs detection is thus critical for early diagnosis of diabetic retinopathy. This paper proposes a novel method for the automated MAs detection in color fundus images based on gradient vector analysis and class imbalance classification, which is composed of two stages, i.e. can...