The use of microarray technology to perform parallel analysis of the expression pattern of a large number of genes in a single experiment has created a new frontier of medical research. The vast amount of gene expression data generated from multiple microarray experiments requires a robust database system that allows efficient data storage, retrieval, secure access, data dissemination, and inte...

The development of microarrays for genome comparison and transcriptional profiling along with the public availability of several meningococcal genome sequences has promoted studies elucidating (i) intraspecific and interspecific genomic differences of members of the genus Neisseria, and (ii) the transcriptional response of meningococci to a variety of environmental stresses such as heat shock, ...

Chemicals released into the environment have a potential to affect on various species and evaluation of the impacts on ecosystems including aquatic organisms is urgent issue. In order to evaluate chemical effects on various species, it is important to understand their mode of action. Recent advances in toxicogenomics, the integration of genomics into toxicology is promising for understanding mo...

Microarrays are invaluable high-throughput tools used to snapshot the gene expression profiles of cells and tissues. Among the most basic and fundamental questions asked of microarray data is whether individual genes are significantly activated or repressed by a particular stimulus. We have previously presented two Bayesian statistical methods for this level of analysis, collectively known as v...

High-throughput microarray technologies have long been a source of data for a wide range of biomedical investigations. Over the decades, variants have been developed and sophistication of measurements has improved, with generated data providing both valuable insight and considerable analytical challenge. The cost-effectiveness of microarrays, as well as their fundamental applicability, made the...

DNA microarrays are one of the most important and widely-used systems for generating genomic data for disease diagnostics and monitoring. The technology supporting DNA microarray production represents a successful combination of ideas from molecular biology, biochemistry, VLSI design and mathematics. Nevertheless, there still exist many issues that have to be resolved in order to ensure very hi...

Comparative Study of Transcriptome Profile and Immune-related Genes Network Associated with Intestinal Epithelial Tissue based on Microarray Data in Poultry Coccidiosis

The ability to provide thousands of gene expression values simultaneously makes microarray data very useful for phenotype classification. A major constraint in phenotype classification is that the number of genes greatly exceeds the number of samples. We overcame this constraint in two ways; we increased the number of samples by integrating independently generated microarrays that had been desi...