A cytogenetic study was performed in lymphocytes of hospital workers occupationally exposed to X- and gamma-rays using the micronucleus centromere assay. A comparison of the data for the exposed group and an age-matched group of non-exposed hospital workers showed a significant (P < 0.05) increase in centromere-positive micronuclei for the radiation workers, while no effect on centromere-negati...

The present study was aimed to investigate the frequency of micronuclei and other nuclear anomalies in alcoholic subjects. The present study included 100 subjects out of which 54 were alcoholics (23 smokers and 31 non smokers) and 46 subjects (non smokers) were healthy controls.The average age of alcoholics was of 44.185±4.434 years, very close to that of control individuals which was 41.281±6....

The ionizing radiation is a known carcinogen as well as cancer therapeutic agent however, the side effect on normal tissue is a limiting factor and inadequate doses necessitates search for an ideal radioprotective agent. Bamboo species are rich source of antioxidants hence have therapeutic value in many free radical mediated diseases. This is the first report regarding in vitro protective effec...

Bubbles that grow during decompression are believed to originate from preexisting gas micronuclei. We showed that pretreatment of prawns with 203 kPa oxygen before nitrogen loading reduced the number of bubbles that evolved on decompression, presumably owing to the alteration or elimination of gas micronuclei (Arieli Y, Arieli R, and Marx A. J Appl Physiol 92: 2596-2599, 2002). The present stud...

Acentric and atelomeric double minute chromatin found in human cancer cells are eliminated from cells by selective incorporation into the micronuclei. We showed previously that most of the micronuclei were formed at S phase and mediated by the nuclear bud-shaped structures that selectively entrap double minutes. In this paper, we have examined the behavior of double minutes in relation to the n...

OBJECTIVE A previous study by our research group evaluated the levels of DNA damage using the comet assay in hemodialysis patients with type 2 diabetes mellitus. The same blood samples were also evaluated using the cytochalasin B micronucleus assay. A comparison of the results of the two assays is presented here. METHODS Whole blood samples were collected from 22 type 2 diabetes mellitus pati...

Abstract Background Bioanalytical tools have been shown to be useful in drinking water quality assessments. Here, we applied a panel of vitro bioassays assess the treatment efficiency two pilot-scale treatments: ozonation and granular activated carbon (GAC) filtration at plant (DWTP). The systems were studied alongside full-scale process consisting biological (BAC) filtration, UV disinfection, ...

both micronuclei (mn) and binuclei (bn) as well as rapd (random amplifying polymorphism of dna) assays are newly biomarkers which are well-introduced in toxic injury and related genotoxicity studies in bivalve, fishes and even humans. however, there is no record of such studies in iranian persian gulf coast line so far. for this propose, we analyzed frequency of mn and rapd patterns in gill cel...