Contamination of groundwater by arsenic, a paradoxical human carcinogen, has become a cause of global public health concern. In West Bengal, India, the groundwater in 9 of 18 districts is heavily contaminated with arsenic. Various adverse health effects including cancer have been reported from these districts and are associated with prolonged arsenic exposure. A cross-sectional biomarker study ...

Stilbenes are secondary metabolites of great interest produced by many plant species due to their important bioactive properties. These phytochemicals have become increasing in the wine industry as a natural alternative sulphur dioxide, which has been associated with human health risks. However, there is still little toxicological information on stilbenes and results thus far contradictory. Con...

Cyclophosphamide is one of the chemotherapeutics for cancer, however this drug has severe side effects in multiple organs and a well-known mutagenic agent. In work protective activity antioxidant-rich Carob (Ceratonia siliqua L.) pods leaves extracts against cyclophosphamide induced genotoxicity was studied. Safety these evaluated acute subacute toxicity tests at dose 1500 mg/kg/day albino rats...

Aims and Objectives: The effectiveness of crude methanolic extracts of Bridelia ferruguinea, Tridax procumbens, Ocimum gratissimum and Lawsonia inermis against clastogenicity induced by sodium arsenite (SA) was evaluated using an in-vivo rat bone marrow cell micronuclei test and the DPPH radical scavenging assay. Methods: 50 mg/kg body weight of the extracts were given by gavaging to the rats i...

BACKGROUND Ionizing radiation causes detrimental health effects such as cancer and genetic damage. The study aim was to determine predictors for micronuclei (MN) occurrence and frequency in peripheral blood lymphocytes of health workers professionally exposed to radiation. METHODS Health workers, age matched, selected for the study on regular check-ups, were divided according to the radiation...

In the present investigation, effects of Ramalina capitata acetone extract on micronucleus distribution on human lymphocytes, on cholinesterase activity and antioxidant activity (by the CUPRAC method) were examined, for the first time as well as its HPLC profile. Additionally, total phenolic compounds (TPC), antioxidant properties (estimated via DPPH, ABTS and TRP assays) and antibacterial acti...

We used the conventional bone marrow micronucleus test complemented with the fluorescent in situ hybridization with the minor satellite DNA probe to investigate the mechanisms of induction of micronuclei in mice treated with camptothecin and its clinical antineoplastic analogues topotecan and irinotecan. All experiments were performed with male Swiss albino mice. Single doses of 1 mg/kg camptot...

RATIONALE DNA damage and chromosomal alterations in peripheral lymphocytes parallels DNA mutations in tumor tissues. OBJECTIVE The aim of our study was to predict the presence of neoplastic colorectal lesions by specific biomarkers in "medium risk" individuals (age 50 to 75, with no personal or family of any colorectal neoplasia). METHODS AND RESULTS We designed a prospective cohort observa...

Beryllium metal has physical properties that make its use essential for very specific applications, such as medical diagnostics, nuclear/fusion reactors and aerospace applications. Because of the widespread human exposure to beryllium metals and the discrepancy of the genotoxic results in the reported literature, detail assessments of the genetic damage of beryllium are warranted. Mice exposed ...

Increase in the production and release of engineered nanoparticles are known to induce genetic alterations that directly and indirectly affect the human health. The present study was aimed to evaluate the genotoxic potential of two metal oxide nanoparticles, silicon dioxide (SiO2-NPs) and titanium dioxide (TiO2-NPs), in human peripheral lymphocyte in vitro. Human peripheral blood cells were cul...