In a previous study of cultured preglomerular vascular smooth muscle cells, it was demonstrated that, although the stable prostacyclin analog iloprost alone had no effect on the intracellular calcium concentration ([Ca2+](i)), it did significantly attenuate the increase in [Ca2+](i) stimulated by angiotensin II (AngII). In this study, the mechanisms by which iloprost interacts with calcium sign...

Levosimendan enhances cardiac contractility primarily via Ca(2+) sensitization, and it induces vasodilation through the activation of ATP-sensitive potassium channels and large conductance Ca(2+)-activated K(+) channels. However, the concentration-dependent hemodynamic effects of levosimendan and its metabolites (R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide (OR-1896...

OBJECTIVE The aim of the present study was to compare the acute effects of inhaled milrinone and inhaled nitroglycerin on pulmonary and systemic hemodynamics in children with acyanotic congenital heart disease (left-to-right shunt) and pulmonary artery hypertension. DESIGN Randomized clinical trial. SETTING Catheterization laboratory of a tertiary care hospital. PARTICIPANTS Thirty-five c...

SURGERY activates the circulating pool of blood platelets. This process is most intense at sites of vascular injury, where platelets adhere and aggregate to plug vascular holes and provide the phospholipid surface necessary for coagulation proteins to assemble and generate fibrin. However, activated platelets can also be detected in blood remote from sites of surgical trauma. These less intensi...