Abstract Background MicroRNAs (miRNAs) have been discovered as novel modulators of gene expression. These molecules are involved in regulating lipid metabolism through a complicated interactive mechanism involving regulatory networks and can play role metabolic diseases. PCSK9 (proprotein convertase subtilisin/Kexin 9) is critical regulator cholesterol homeostasis. inhibition an effective thera...

In this issue of the JCI, Trudeau and colleagues make a bold statement: “We show, we believe for the first time, that the development of an autoimmune disease can be predicted based on the presence of antigen-specific cytotoxic T cells in the peripheral blood.” (1). We suspect that, like most “firsts,” this one will be challenged. Nevertheless, based on recent workshops showing the difficulty a...

Martin Kirschner cirujano alemán que empleó por primera vez alambres para la fijación de las fracturas, éstos en la actualidad son de uso frecuente en el tratamiento ortopédico, también desarrolló un abordaje para rodilla, cirugías en las extremidades, así como un método para realizar un esófago artificial, él fue primero en realizar una embolectomía de la arteria pulmonar llamada operación de ...

CONTEXT AND OBJECTIVE Pedicled flaps play an important role in cancer treatment centers, particularly in developing and emerging countries. The aim of this study was to identify factors that may cause complications and influence the final result from reconstructions using pectoralis major myocutaneous flaps (PMMFs) for head and neck defect repair following cancer resection. DESIGN AND SETTING...