Abstract Introduction The prevalence of depression and anxiety among young adults (YA) rose precipitously in the last decade, along with a rise provision first-line antidepressants known as selective serotonin reuptake inhibiters (SSRIs). SSRIs are associated extremely high rates nonadherence - above 50% for all patients accentuated those under 35 years old. Concurrently, sexual dysfunction is ...

objective(s):this study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (i/r) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. it also examined the effects of the drugs aimed at preventing infertility that may result from i/r injury. materials and methods: diabetic rats were divided into ...

Smoking increases metabolism of different medications including some antidepressants (tricyclics and mirtazapine), antipsychotics (clozapine, olanzapine and haloperidol) [14], some benzodiazepines and opiates.[15] This can result in significantly lower plasma levels [12] and therefore, larger doses are required for a similar therapeutic effect. However, following smoking cessation, doses of the...

Smoking increases metabolism of different medications including some antidepressants (tricyclics and mirtazapine), antipsychotics (clozapine, olanzapine and haloperidol) [14], some benzodiazepines and opiates.[15] This can result in significantly lower plasma levels [12] and therefore, larger doses are required for a similar therapeutic effect. However, following smoking cessation, doses of the...

OBJECTIVES Naturalistic studies comparing differences in risks across antidepressant agents must take into account factors which influence selection of specific agents and may be associated with outcomes. We examined predictors of antidepressant choice among VA patients treated for depression. METHODS Retrospective cohort study of VA patients with depression diagnoses and a new start of one o...

Case report. In 2005, Mr. A, a nonobese 40-year-old man (body mass index = 26 kg/m), developed a syndrome consistent with schizophrenia. He was treated with high doses of risperidone (8 mg); after he subsequently developed a hypokinetic-rigid syndrome, biperiden (2 mg) was added. However, it soon became apparent that the psychosis was followed by a major depressive episode (his Hamilton Rating ...