Lung surfactant proteins (SP) A and D are calcium-dependent carbohydrate-binding proteins. In addition to playing multiple roles in innate immune defense such as bacterial aggregation and modulation of leukocyte function, SP-A and SP-D have also been implicated in the allergic response. They interact with a wide range of inhaled allergens, competing with their binding to cell-sequestered IgE re...

In this October, we are having the most important allergy festival in Asia-Pacific region the Joint Congress of Asia Pacific Association of Allergy, Asthma, and Clinical Immunology (APAAACI) and Asia Pacific Association of Pediatric Allergy, Respiratory, and Immunology in Kuala Lumpur, Malaysia (October 17–20, 2016, http://www.apaaaci-kl2016.org). The Joint Congress will be hosted by the Malays...

An occurrence of acute localised myelitis was recently seen in four adult patients with atopic dermatitis who had hyperIgEaemia and mite antigen specific IgE. The total and mite antigen specific IgE was therefore studied in serum samples from 19 consecutive patients with acute localised myelitis of unknown aetiology, 56 patients with clinically definite multiple sclerosis, and 40 healthy contro...

Background. Studies suggest that early-life gut microbiota composition and intestinal short-chain fatty acids (SCFAs) are linked to future asthma susceptibility. Furthermore, infancy offers a critical time window modulate the associated metabolites through diet-microbe interactions promote infant health. Human milk oligosaccharides (HMOs), nondigestible carbohydrates abundant in breast milk, pr...

BACKGROUND Sublingual immunotherapy (SLIT) as a therapy for the treatment of allergic rhinitis in children might be acceptable as an alternative for subcutaneous immunotherapy. However, the efficacy of SLIT with house dust mite extract is not well established. OBJECTIVE To investigate whether SLIT in house dust mite-allergic children recruited in primary care is effective and safe. METHODS ...

Since the late 20th century, environmental exposure to endotoxins has been very low and type I allergic disease increased. In addition, we have increased PM2.5 other chemicals. Recently, there is concern that daily use of hygiene products containing antimicrobial substances associated with an prevalence allergies. It noted these may exacerbate our study, confirmed intratracheal administration a...

We examined associations between reported home characteristics and levels of indoor allergens in 499 homes of a birth cohort of children of allergic/asthmatic families from the Boston area. The risk of having dust mite allergen (Der f 1 or Der p 1) > or = 2 microg/g on the bedroom floor was highest in houses, but 16% of apartments had levels this high. Compared with that from smooth floors, dus...

BACKGROUND Although exposure to house dust mite allergen is a major risk factor for allergic sensitization and asthma, nationwide estimates of dust mite allergen levels in US homes have not been reported. OBJECTIVE The purpose of this study was to estimate the prevalence of dust mite allergen in beds of US homes and to identify predictors of dust mite allergen concentration. METHODS Data we...