Neuroplasticity is a fundamental mechanism of neuronal adaptation to external and internal stimuli. There are evidences that chronic stress and mood disorders disrupt neuroplasticity, while antidepressant treatment can enhance neuroplasticity. Mitochondria strongly affect many intracellular processes coupled to plasticity and neuron survival. Mitochondrial dysfunctions are assuming an increasin...

From Parkinson’s disease to an ischemic stroke, a consistently reoccurring theme in the context of neuronal degeneration is the dysfunction of mitochondria as the underlying factor. Insight into the mechanistic basis for mitochondrial dysfunction in neurodegenerative disorders has allowed the theme of mitochondrial dynamics to be highlighted as a central player. The precise balance of mitochond...