The unique ability of cell-penetrating peptides (CPPs), also known as protein transduction domains, to navigate across the nonpolar biological membrane has been under intense investigation. In vitro studies have shown that multiple mechanisms are available, with the precise details being dependent on the peptide and cell line studied. The several clearly demonstrated pathways include various fo...

High-throughput experimentation (HTE) can be a powerful tool in chemical research, and the large datasets it generates could play role applying machine-learning methods to predictions. But high-throughput sometimes viewed as inaccessible academic chemist. This Voices, conjunction with our recent panel (https://www.brighttalk.com/webcast/16651/499811), asks: what are myths associated experimenta...

N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate is presented. The reactions were performed in polar aprotic solvents and with avoidance of polymerization of acrylic substrate. The obtained adducts may serve as versatile substrates for further functionalization, e.g. into (3-uracil-1-yl)propanoic acids or transformations, with participation of hydro...

(2S,4R)and (2S,4S)-perfluoro-tert-butyl 4hydroxyproline were synthesized (as Fmoc-, Boc-, and free amino acids) in 2−5 steps. The key step of each synthesis was a Mitsunobu reaction with perfluoro-tert-butanol, which incorporated a perfluoro-tert-butyl group, with nine chemically equivalent fluorines. Both amino acids were incorporated in model α-helical and polyproline helix peptides. Each ami...

The development of new reactions is important to improve the toolbox organic chemistry. One way nudge a reaction undergo pathway different from what it normally takes. Stereoinvertive SN2 known be intolerant bulky tertiary carbon centers, which tend proceed through SN1 pathways form racemized products. This leads long-standing challenge in synthesis; that is, how prepare enantiopure compounds s...

Synthetic protocols and circular dichroism (CD) spectra are reported for a series of oligomers of (R,R)-trans-2-aminocyclopentanecarboxylic acid (trans-ACPC). The two longest oligomers, a hexamer and an octamer, have also been examined crystallographically. Both crystal structures show that the â-peptide backbone adopts a regular helix that is defined by a series of interwoven 12-membered ring ...

For the fabrication of practical E-O devices, critical material requirements, such as large E-O coefficients, high stability (thermal, chemical, photochemical, and mechanical), and low optical loss, need to be simultaneously optimized.1 In the past decade, a large number of highly active nonlinear optical (NLO) chromophores have been synthesized, and some of these exhibit very large macroscopic...

Derivatives of 3 -amino-5-cholestene (3 -cholesterylamine) are of substantial interest as cellular probes and have potential medicinal applications. However, existing syntheses of 3 -amino-5-cholestene are of limited preparative utility. We report here a practical method for the stereoselective preparation of 3 -amino-5-cholestene, 3 -chloro-5-cholestene, 3 -bromo-5-cholestene, and 3 -iodo-5-ch...

Open AccessCCS ChemistryRESEARCH ARTICLE1 Jul 2021Palladium-Catalyzed O- and N-Glycosylation with Glycosyl Chlorides Shuang An†, Quanquan Wang†, Wanjun Zhu, Qikai Sun, Gang He Gong Chen An† State Key Laboratory Institute of Elemento-Organic Chemistry, College Nankai University, Tianjin 300071 †S. An Q. Wang contributed equally to this work.Google Scholar More articles by author , Wang† Zhu Goog...

Open AccessCCS ChemistryRESEARCH ARTICLE1 Jun 2021Optically Active Nucleobase-Functionalized Polynorbornenes Mimicking Double-Helix DNA Li Wang, Nan Lu, Shuai Huang, Meng Xu-Man Chen and Hong Yang Wang School of Chemistry Chemical Engineering, Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, Institute Advanced Materials, Southeast University, Nanjing 211189 Google Scholar More ...