BACKGROUND Musladin-Lueke Syndrome (MLS) is a hereditary disorder affecting Beagle dogs that manifests with extensive fibrosis of the skin and joints. In this respect, it resembles human stiff skin syndrome and the Tight skin mouse, each of which is caused by gene defects affecting fibrillin-1, a major component of tissue microfibrils. The objective of this work was to determine the genetic bas...

The maximum-likelihood-binomial (MLB) method, based on the binomial distribution of parental marker alleles among affected offspring, recently was shown to provide promising results by two-point linkage analysis of affected-sibship data. In this article, we extend the MLB method to multipoint linkage analysis, using the general framework of hidden Markov models. Furthermore, we perform a large ...

In this work we present a high-accurate discretization to solve the compressible Navier-Stokes equations using an Arbitrary Lagrangian-Eulerian meshless method (SPH-MLS), which can be seen as general formulation that includes some well-known meshfree methods particular case. The is based on use of Moving Least Squares (MLS) approximants weight functions Galerkin and accurate discretize convecti...

Abstract Objectives Data on the consumption of macrolides, lincosamides and streptogramins (MLS) in community were collected from 30 EU/European Economic Area (EEA) countries over two decades. This article reviews temporal trends, seasonal variation, presence change-points changes composition main subgroups MLS. Methods For period 1997–2017, data MLS, i.e. ATC group J01F, aggregated at level ac...

Magnetic Levitation System (MLS) is one of the benchmark laboratories models for designing and testing feedback control systems in presence parametric uncertainties disturbances effect. Therefore, MLS can be regarded as a tool to study verify certain robust controller design. In this paper, two types powerful schemes are presented MLS. The first PI-PD controller, while other fractional order FO...

Abstract For the first time, processes controlling variations of mixed layer temperature (MLT) and salinity (MLS) in Banda Sea are quantified using data from a single Argo float combination with satellite reanalysis outputs August 2017 to 2019. This augments previous studies that utilized ocean model only. We document presence barrier quantify roles air-sea heat mass exchanges, horizontal advec...

Background Little is known about career length after anterior cruciate ligament (ACL) reconstruction in Major League Soccer (MLS), the top men's professional soccer league in the United States. Further, it is unspecified whether athletes returning to soccer after ACL reconstruction are at a higher risk for injuries, beyond new knee injuries. Purpose To examine career length and the incidence ...

The accurate and robust reconstruction of a digital representation using 3D scanning technologies is an important task in many application field. An important problem in this field is the integration of multiple range maps in a single polygonal surface. In this paper we describe a robust and effective implementation of a reconstruction algorithm based on implicit representation which, thanks to...

A package of Lisp functions is described which implements a simple multi-level simulation toolkit, MLS. Its design owes a great deal to MIMOSE. MLS runs within Lisp-Stat. It offers a set of functions, macros and objects designed to make the specification of multi-level models straightforward and easy to understand. Lisp-Stat provides a Lisp environment, statistical functions and easy to use gra...