نتایج جستجو برای: mmc model
تعداد نتایج: 2106802 فیلتر نتایج به سال:
PURPOSE To evaluate ocular straylight before and after photorefractive keratectomy (PRK) for low myopia with and without topical mitomycin (MMC) treatment. METHODS Patients who underwent PRK for low myopia were enrolled into the study. PRK without MMC was performed in 21 eyes (12 patients), whereas PRK with topical 0.02% MMC was performed in 25 eyes (14 patients). Both groups were treated usi...
In mice and humans, the immunologic effects of developmental exposure to noninherited maternal antigens (NIMAs) are quite variable. This heterogeneity likely reflects differences in the relative levels of NIMA-specific T regulatory (T(R)) versus T effector (T(E)) cells. We hypothesized that maintenance of NIMA-specific T(R) cells in the adult requires continuous exposure to maternal cells and a...
The paper introduces the notion of multimodal cluster (MMC). MMC is a multicomponent spoken unit, which includes diads “meaning + gesture”, “meaning + phonetic phenomenon” (double MMC) or triad “meaning + gesture + phonetic phenomenon” (triple MMC). All components of the same MMC are synchronized in the speech, gestural and phonetic components conveying the same idea as the semantic component (...
purpose: to assess alterations in parameters measured by the ocular response analyzer (ora) after photorefractive keratectomy (prk) with or without 0.02% mitomycin c (mmc) in myopic eyes. methods: in 33 right eyes of 33 patients, iop was determined using the goldmann applanation tonometry (gat) before and 3 months after prk. corneal hysteresis (ch), corneal resistance factor (crf), goldmann-cor...
PURPOSE To investigate how mitomycin C (MMC) modulates corneal fibroblast migration and its molecular mechanisms in the wound healing process. METHODS After treatment with 0 and 0.2 mg · mL(-1) MMC for 5 minutes, effect of MMC on cell migration of human corneal fibroblasts (HCFs) was examined with a cell migration assay. Both focal adhesion kinase (FAK) and paxillin (PXN) expressions in HCFs ...
The bioreductive activation of the antitumor quinone mitomycin C (MMC) by NAD(P)H: quinone oxidoreductase 1 (NQO1) is complicated by the ability of MMC to also act as a mechanism-based inhibitor of NQO1 in a pH dependent manner. Inhibition of NQO1 by MMC has been studied in purified enzyme preparations and in cultured cells but has not determined in vivo. In the studies presented here, NQO1 act...
Metabolomic evaluation of Mitomycin C and rapamycin in a personalized treatment of pancreatic cancer
In a personalized treatment designed for a patient with pancreatic cancer resistant to other treatments, the success of Mitomycin C (MMC) has been highlighted. This was revealed in a murine xenograft tumor model encompassing pancreatic adenocarcinoma cells extracted from the patient. The patient was found to exhibit a biallelic inactivation of the PALB2 gene, involved in DNA repair in addition ...
Myelomeningocele (MMC), the most severe form of spina bifida, is a common and devastating malformation. Over two decades of experimental work in animal models have led to the development and clinical application of open fetal surgery for the repair of the MMC defect. This approach offers improved neurofunctional outcomes and is now a clinical option for the management of prenatally diagnosed MM...
PURPOSE One obstacle to providing early intervention to infants with myelomeningocele (MMC) is the challenge of quantifying impaired neuromotor control of movements early in life. METHODS We used the nonlinear analysis tool Approximate Entropy (ApEn) to analyze periodicity and complexity of supine spontaneous lower extremity movements of infants with MMC and typical development (TD) at 1, 3, ...
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