Matrix-Matrix Multiplication (MMM) is a fundamental operation in scientific computing. Achieving the floating point peak with this operation requires expert knowledge of linear algebra and computer architecture to craft a tuned implementation, for a given microarchitecture. The expert follows a mechanical process for implementing MMM, by deriving the algorithm models from the literature. Then, ...

Introduction Myelofibrosis with myeloid metaplasia (MMM) represents both agnogenic myeloid metaplasia (AMM) and the fibrotic stages of polycythemia vera (PV) and essential thrombocythemia (ET). The latter two conditions are also referred to as post polycythemic myelofibrosis (PPM) and post thrombocythemic myelofibrosis (PTM). MMM is currently classified under the broad category of chronic myelo...

Patients with myelofibrosis with myeloid metaplasia (MMM) often experience debilitating constitutional symptoms such as drenching night sweats, profound fatigue, unexplained fevers, and unintentional weight loss. Tumor necrosis factor (TNF) contributes to organ fibrosis and hypercatabolic symptoms in a variety of disease states. We conducted an open-label pilot study of etanercept, a soluble TN...

Joel S. Tieder, MD, MPH, FAAP, Joshua L. Bonkowsky, MD, PhD, FAAP, Ruth A. Etzel, MD, PhD, FAAP, Wayne H. Franklin, MD, MPH, MMM, FAAP, David A. Gremse, MD, FAAP, Bruce Herman, MD, FAAP, Eliot S. Katz, MD, FAAP, Leonard R. Krilov, MD, FAAP, J. Lawrence Merritt II, MD, FAAP, Chuck Norlin, MD, FAAP, Jack Percelay, MD, MPH, FAAP, Robert E. Sapién, MD, MMM, FAAP, Richard N. Shiffman, MD, MCIS, FAAP...

BACKGROUND Changes in patient length of stay (the duration of 1 clinic visit) as a result of the introduction of an electronic patient file system forced an anesthesia department to change its outpatient clinic organization. In this study, we sought to demonstrate how the involvement of essential employees combined with mathematical techniques to support the decision-making process resulted in ...

This paper describes a Meta-Modeling Framework (MMF) that addresses many of the deficiencies in the definition of The unified Modeling Language (UML), and promises to support the OMG's newly announced strategy, Model Driven Architecture (MDA) [OMG01]. The facility comprises a language (MML) for defining modeling notations, a tool (MMT) that checks and executes those definitions, and a method (M...

The potential benefit from introducing trajectory based operations into the NAS is estimated in this paper. Delay predictions of a stochastic and a deterministic queuing model, which represent high and low levels of trajectory uncertainty, are compared. It is found that delay savings are on the order of 35% in the average case, Delay predictions from the various models are found to be strongly ...

This paper deals with the delay analysis of the traffic within the UMTS Terrestrial Radio Access Network (UTRAN). Delay is a very important Quality of Service aspect in the UTRAN. Especially, the delay over the Iub link is the major limited factor for the dimensioning of the UTRAN. Based on the system analysis, a queuing model is proposed in this paper to derive the delay time over the Iub inte...

Multiparticle tracking with scanning confocal and multiphoton fluorescence imaging is increasingly important for elucidating biological function, as in the transport of intracellular cargo-carrying vesicles. We demonstrate a simple rapid-sampling stochastic scanning multifocal multiphoton microscopy (SS-MMM) fluorescence imaging technique that enables multiparticle tracking without specialized ...

Splenic extramedullary hematopoiesis is an integral component of myelofibrosis with myeloid metaplasia (MMM) and may be classified into 3 distinct histologic patterns of infiltration by myeloid precursors: diffuse, nodular, and a predominance of immature granulocytes. These 3 histologic patterns occurred in 121 (56.8%), 75 (35.2%), and 17 (8%), respectively, of 213 patients with MMM who underwe...