Cells of the monocyte/macrophage lineage are involved in the development of inflammatory joint diseases such as rheumatoid arthritis. This disease is characterized by cartilage degradation and synovial membrane inflammation with a progressive loss of joint function. The pathological processes are still not well understood. Therefore it would be interesting to develop a suitable experimental in ...

BACKGROUND Altered matrix degradation contributes to fibrosis in some liver diseases but the role of matrix degradation in fibrogenesis associated with genetic haemochromatosis has not previously been addressed. AIMS To measure serum concentrations of tissue inhibitor of metalloproteinase 1 (TIMP-1) and matrix metalloproteinases (MMP), MMP-1, MMP-2, and MMP-3 in patients with haemochromatosis...

conclusions our results suggest that tetracyclines dose-dependently inhibit mmp-9 activity, and among the common clinical tetracyclines, minocycline provides the most potent inhibition of excess mmp-9 activity and its consequences. materials and methods an mmp-9-rich culture medium of u-937 cells was used as the source of the enzyme. serial dilutions of 5, 20, 100, 200, and 500 µm of each drug ...

Purpose - to systematically examine the state of interrelatedness between serum concentration matrix metalloproteinase 1 and tissue inhibitor 1, frequency acute respiratory infections (ARIs), a heterogeneous set other clinical laboratory parameters in preschool children. Materials methods. Forty children (21 boy 33 girls) aged 6 years old, undergoing inpatient treatment on infection, were invol...

RATIONALE Pulmonary cavitation is fundamental to the global success of Mycobacterium tuberculosis. However, the mechanisms of this lung destruction are poorly understood. The biochemistry of lung matrix predicts matrix metalloproteinase (MMP) involvement in immunopathology. METHODS We investigated gene expression of all MMPs, proteins with a disintegrin and metalloproteinase domain, and tissu...