Reported is a rationally-designed one-pot sequential strategy that allows homoallylic alcohols to be employed in a catalytic, asymmetric, direct vinylogous aldol reaction with a series of activated acyclic ketones, including trifluoromethyl ketones, γ-ketoesters, and α-keto phosphonates, in high yields (up to 95%) with excellent regio- and enantio-selectivity (up to 99% ee). This modular combin...

We report a systematic study of a modular approach to create multi-component supramolecular nanostructures that can be tailored to be both enzyme and temperature responsive. Using a straightforward synthetic approach we functionalised a thermal responsive polymer, poly(2-isopropyl-2-oxazoline), with fluorenylmethoxycarbonyl-amino acids that drive the self-assembly. Depending on the properties o...

We assess the utility of integrating a predetermined aptamer DNA module adjacent to a random catalytic DNA region for identifying new deoxyribozymes by in vitro selection. By placing a known ATP aptamer next to an N40 random region, an explicitly modular DNA catalyst for tyrosine side chain phosphorylation is identified. The results have implications for broader identification of deoxyribozymes...

MOTIVATION Similarities in core residue packing provide evidence for divergence or convergence not reported using other methods. RESULTS We apply a new method for rapid structure comparison based on Simplicial Neighborhood Analysis of Protein Packing (SNAPP) to the diverse structural classification of proteins (SCOP) alpha/beta-class of protein folds. The procedure identifies inter-residue pa...

‎In this paper‎, ‎first we introduce the notion of $frac{1}{2}$-modular metric spaces and weak $(alpha,Theta)$-$omega$-contractions in this spaces and we establish some results of best proximity points‎. ‎Finally‎, ‎as consequences of these theorems‎, ‎we derive best proximity point theorems in modular metric spaces endowed with a graph and in partially ordered metric spaces‎. ‎We present an ex...

Many eukaryotic signal transduction proteins have component-based architectures: they are built from combinations of protein interaction domains and catalytic domains. Intact, these proteins display the sophisticated allosteric behavior required for cellular regulation; the protein's output activity is tightly repressed under basal conditions, but can be robustly activated by a specific set of ...

Interactive systems are constantly evolving. This evolution leads to new challenges. One of these challenges pertains to the quality of dialogue between interactive systems and humans. This dialogue essentially takes place through user interfaces. User interface evaluation is essential to improve communication between a system and its users. The research on interface evaluation is plentiful. Ne...

• Dry pressure drop for two types of complex structured packing is evaluated experimentally and numerically. A numerical model established validated with an average deviation ≤ 20% from the experimental data. The advantages/drawbacks results different computational domains dry study are presented. a wire-based column 16,500 cm 3 produced using periodic rectangular domain 42 . effect penalty on ...