INTRODUCTION Some long-term nicotine gum users are addicted to nicotine and may need assistance to stop. There is no published evidence on the use of nicotine patches for this purpose. CASE DESCRIPTION A 45-year old man presented with a 30-year history of high-dose nicotine gum use (up to 200mg nicotine per day). He was highly nicotine dependent and had failed repeatedly to stop using nicotin...

The objective of the present study was to design an oral controlled drug delivery system for sparingly soluble diclofenac sodium (DCL) using guar gum as triple-layer matrix tablets. Matrix tablet granules containing 30% (D1), 40% (D2) or 50% (D3) of guar gum were prepared by the conventional wet granulation technique. Matrix tablets of diclofenac sodium were prepared by compressing three layers...

The purpose of this research was to develop gastro-retentive delivery system of atenolol which, after oral administration should have the ability to prolong gastric residence time with desired in vitro release profile. Atenolol was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by direct compression technique, using natural ...

Engineering projects often undergo several design iterations before being completed. Information received from other groups working on a project (analysis, manufacturing, marketing, sales) will often necessitate changes in a design. The interaction between different groups associated with a design project often takes the form of informal “negotiation.” This form of interaction commonly arises w...

the effect of addition of qodumeh shahri (lepidium perfoliatum) seed gum on the emulsion properties were investigated in this study. l. perfoliatum seed gum with 0-0.6% (w/w) concentration was used together with 2% (w/w) wpc to emulsify 20% (w/w) corn oil. the emulsion was analyzed for emulsion stability, particle size, specific surface area, particle size distribution and rheological propertie...