objective: this study examined the in vivo differentiation of mesenchymal stem cells (mscs) into insulin producing cells (ipcs) on electrospun poly-l-lactide acid (plla) scaffolds coated with matricaria chammomila l. (chamomile) oil. materials and methods: in this interventional, experimental study adipose mscs (amscs) were isolated from 12 adult male new zealand white rabbits and characterized...

Axon guidance is required for the establishment of brain circuits. Whether much molecular basis axon known from animal models, machinery coordinating growth and pathfinding in humans remains to be elucidated. The use induced pluripotent stem cells (iPSC) human donors has revolutionized vitro studies brain. iPSC can differentiated into neuronal which used generate neural tissue-like cultures, as...

multiple sclerosis (ms) is an autoimmune disease of the central nervous system (cns) which causes demyelination of the nerve fibers. the etiology of this disease is not well understood but it is believed that t helpers play a central role in ms. numerous findings support the view that th17 cells play an essential role in pathogenesis of ms and il-17 secreting t (th17) cells have a role in infla...

Background: Due to intrinsic heterogeneity of cellular distribution and density within diffusion weighted images (DWI) of glioblastoma multiform (GBM) tumors, differentiation of active tumor and peri-tumoral edema regions within these tumors is challenging. The aim of this paper was to take advantage of the differences among heterogeneity of active tumor and edematous regions within the gliobla...

ABSTRACT The differentiation of distinct cell types in appropriate patterns is a fundamental process the development multicellular organisms. In Arabidopsis thaliana, protoderm/epidermis differentiates as single layer at outermost position. However, little known about molecular nature positional signals that achieve correct epidermal differentiation. Here, we propose very-long-chain fatty acid-...

Pluripotent stem cells can self-renew in culture and differentiate along all somatic lineages in vivo. While much is known about the molecular basis of pluripotency, the mechanisms of differentiation remain unclear. Here, we profile individual mouse embryonic stem cells as they progress along the neuronal lineage. We observe that cells pass from the pluripotent state to the neuronal state via a...

OBJECTIVE Hyaluronan (HA) plays a role in keratinocyte proliferation and differentiation. In addition, HA has been shown to have different biological activities depending on its molecular weight. It has been reported that HA-mediated CD44 activation regulates keratinocyte differentiation. Therefore, the aim of this study was to investigate the influence of HA tetrasaccharides (HA4) on the regul...

Background—Embryonic stem cell (ESC)–derived cardiomyocytes are anticipated to serve as a useful source for future cell-based cardiovascular disease therapies. Research emphasis is currently focused on determining methods to direct the differentiation of ESCs to a large population of cardiomyocytes with high purity. To this aim, understanding the molecular mechanisms that control ESC-to-cardiom...

shigella species are among the common causes of bacterial diarrhoeal diseases. traditional detection methods are time-consuming resulting in delay in treatment and control of shigella infections thus there is a need to develop molecular methods for rapid and simultaneous detection of shigella spp. in this study a rapid multiplex pcr were developed for simultaneous detection of three pathogenic ...