Abstract. The triple-negative breast cancer cell line MDA-MB-231 has been known as one of the most tenacious cells and paid attention by many researchers. A two-dimension quantitative structure-activity relationship (2D-QSAR) model 131 benzimidazole derivatives was developed to relate chemical–biological interactions predicted half maximal inhibitory concentration (IC50) against line. 2D-QSAR o...

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the etiologic agent of current pandemic corona virus disease 2019 (COVID-19) that has inflicted loss thousands lives worldwide. The coronavirus surface spike (S) glycoprotein a class I fusion with S1 domain which attached to human angiotensin converting enzyme (ACE2) receptor, and S2 enables host cell membrane internalization virus...