نتایج جستجو برای: molecular probes
تعداد نتایج: 670481 فیلتر نتایج به سال:
Strategies for the development of new molecular sensors and reporters have captivated the attention of researchers for many centuries. These molecular probes have been instrumental to many pioneering discoveries in chemistry, biology, and medicine. Until recently, most of the available dyes were photoactive at the visible wavelengths, and analytical instruments were optimized for use in this re...
Three Low Molecular Weight Fluorescent probes (LMFPs) coumarin-enamine (3a-c) have been synthesized, and their photophysical properties studied in different solvent systems (DMSO, CH3CN, DMF, MeOH, EtOH, Me2CO, MeCO2Et, CHCl3, C6H5Me, C6H6). Dimethyl sulfoxide was chosen as the optimum to investigate 3a for organophosphate detection. On deprotonation of oxime, a significant spectroscopic shift ...
Here we introduce diffusion molecular retention (DMR) tumor targeting, a technique that employs PEG-fluorochrome shielded probes that, after a peritumoral (PT) injection, undergo slow vascular uptake and extensive interstitial diffusion, with tumor retention only through integrin molecular recognition. To demonstrate DMR, RGD (integrin binding) and RAD (control) probes were synthesized bearing ...
Proteases play important roles during tumor angiogenesis, invasion, and metastasis. Various molecular imaging techniques have been employed for protease imaging: optical (both fluorescence and bioluminescence), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and positron emission tomography (PET). In this review, we will summarize the current status of imag...
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