A highly practical and efficient preparation of 6-methy-4H-thiochromene and 7-methyl-thiochromene[2,3-d]pyrimidine derivatives was developed via a multi-component reaction of 3-methyl-thiophenol (1), aldehydes (2), and malononitrile (3). A series of pyrimidine nucleoside, thiochromene[2,3-d]pyrimidine and thiochromene[2,3-d]pyrimidine-10-sulfone was efficiently obtained. These hybrid compounds ...

W. S. H am am a Chemistry D epartm ent, Faculty of Science, M ansoura University, M ansoura, Egypt R eprint requests to Dr. W. S. H am am a. E-mail: Sinfac@ mum.mans.eun.eg Z. Naturforsch. 55b, 443-447 (2000); received January 25, 2000 6-Am inouracil, M annich Reaction, Pyrimido[4,5-d]pyrim idine The reaction of 6-am inouracil 1 with form aldehyde and secondary amines in ethanol at room tem per...

Bromination of N-substituted homophthalimides and tetrahydropyrido[4,3-d]- pyrimidine-5,7-diones produces 4,4-dibromohomophthalimide and 8,8-dibromo-tetrahydropyrido[4,3-d]pyrimidine-5,7-dione derivatives, respectively, that can be used as precursors for spiro derivatives. The dibromo derivatives react with different binucleophilic reagents to produce several spiroisoquinoline and spirotetrahyd...

Abstract Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds. They are important and widely represented in medicinal chemistry as they structural analogs of purines. have various biological activities. The current review discusses different synthetic methods for the preparation heterocyclic thienopyrimidine derivatives. It also highlights most recent research on ...