Bronchoprovocation with cysteinyl-leukotrienes (LTs) induces airflow obstruction and gas exchange abnormalities, namely ventilation-perfusion ratio (V'(A)/Q') imbalance. However, it is unknown which of the two different receptors for cysteinyl-LTs mediate these V'(A)/Q' disturbances. In a double-blinded, crossover design, 10 patients with mild asthma were randomised to receive an oral single do...

OBJECTIVES Children with nonsevere obstructive sleep apnea (OSA) benefit from alternative therapeutic interventions such as leukotriene modifiers. We hypothesized that montelukast might improve OSA in children. We tested this hypothesis in a double-blind, randomized, placebo-controlled fashion. METHODS Of 50 possible candidates, we recruited 46 children with polysomnographically diagnosed OSA...

BACKGROUND The response to beta2-adrenoceptor agonists is reduced in asthmatic airways. This desensitization may be in part due to inflammatory mediators and may involve cysteinyl-leukotrienes (cysteinyl-LTs). Cysteinyl-LTs are pivotal inflammatory mediators that play important roles in the pathophysiology of asthma, allergic rhinitis, and other inflammatory conditions. We tested the hypothesis...

Prostate cancer is a devastating disease for which current therapies are inadequate. Various lines of evidences have suggested the 5-lipoxygenase (5-LOX) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of Prostate cancer. Thus, search for new anti-cancer drugs targeting 5-LOX and leukotriene is very essential and important. The objective of the pre...

The present study aims to formulate mouth dissolving tablets of montelukast sodium by direct compression method for the faster action, better absorption and improvement bioavailability drug in management Asthma. Total six formulations were developed with varying concentrations combination Crosspovidone Sodium starch glycolate as super disintegrating agents. prepared method. MDT evaluated variou...

247 Health-Related Quality of Life and Prognostic Value of Acoustic Rhinometry in Patients With Perennial Allergic Rhinitis Treated with Fix Combination of Montelukast Plus Desloratadine Cemal Cingi, MD, ORL & HNS, Fatih Oghan, MD, ORL & HNS, DPU, Gorkem Eskiizmir, MD, ORL & HNS, Aytekin Yaz, MD, ORL & HNS, Ahmet Ural, ORL & HNS, and Nagehan Erdogmus, ORL & HNS. Osmangazi University, Faculty of...

247 Health-Related Quality of Life and Prognostic Value of Acoustic Rhinometry in Patients With Perennial Allergic Rhinitis Treated with Fix Combination of Montelukast Plus Desloratadine Cemal Cingi, MD, ORL & HNS, Fatih Oghan, MD, ORL & HNS, DPU, Gorkem Eskiizmir, MD, ORL & HNS, Aytekin Yaz, MD, ORL & HNS, Ahmet Ural, ORL & HNS, and Nagehan Erdogmus, ORL & HNS. Osmangazi University, Faculty of...

BACKGROUND Cysteinyl leukotrienes are capable of inducing chemotaxis of eosinophils in vitro and within the airways of animals and humans in vivo. OBJECTIVE We hypothesized that montelukast (MK-0476), a potent cysLT1 receptor antagonist, would protect against allergen-induced early (EAR) and late (LAR) asthmatic responses by virtue of anti-inflammatory properties. Hence, we studied the effect...

1 Nathan RA, Yancey SW, Waitkus-Edwards K, et al. Fluticasone propionate nasal spray is superior to montelukast for allergic rhinitis while neither affects overall asthma control. Chest 2005; 128:1910–1920 2 Robinson DS, Campbell D, Barnes PJ. Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial. Lancet 2001; 357:2007–20...

RESULTS. Almost 600 patients were randomized to each treatment arm. Almost 75% of patients had a least 1 episode of asthma, with almost half of patients culminating in an exacerbation. No significant difference was seen between groups in the number of episodes leading to asthma exacerbations. Daily montelukast reduced symptoms over the 12-day treatment period of asthma episodes compared with pl...