نتایج جستجو برای: morphine antinociception tolerance
تعداد نتایج: 142066 فیلتر نتایج به سال:
introduction: several researches have reported that stress is able to inhibit the development of morphine tolerance via activating of hypothalamic-pituitary-adrenal (hpa) axis. in the present study we tried to examine the effect of epinephrine, the product of adrenal medulla, on the development of morphine tolerance. methods: analgesic tolerance was induced by intrathecal (i.t.) injection of mo...
OBJECTIVE To compare the antinociceptive effects of magnesium sulphate (MgSO(4)) when administered epidurally alone and in combination with morphine. STUDY DESIGN Experimental, randomized, 'blinded', crossover study. ANIMALS Six healthy adult Beagle dogs. METHODS Evaluated treatments were MgSO(4) (2.5 mg kg(-1)) alone (Mg), morphine (0.1 mg kg(-1)) alone (Mo), MgSO(4) in combination with ...
BACKGROUND AND PURPOSE We demonstrated previously that oxycodone has potent antinociceptive effects at supraspinal sites. In this study, we investigated changes in neuronal function and antinociceptive mechanisms of oxycodone at ventrolateral periaqueductal gray (VLPAG) neurons, which are a major site of opioid action, in a femur bone cancer (FBC) model with bone cancer-related pain. EXPERIME...
by Kimberly T. Tsutsui, M.S. Washington State University May 2010 Chair: Rebecca. M. Craft Use of anabolic-androgenic steroids (AAS) has been anecdotally associated with pain reduction as well as opioid abuse. The purpose of the current study was to investigate the effects of AAS on nociception and morphine antinociception in acute pain models, as well as on chronic nociception in an arthritis ...
We have examined the involvement of serine/threonine protein phosphatase (PP) sensitive to okadaic acid (OA) in the antinociceptive effect of morphine in mice. The present study was performed to elucidate subcellular distribution and activity of OA-sensitive PPs in the brain when mice exposed to morphine. Subcutaneous administration of morphine (5 mg/kg) produced the antinociceptive effect with...
Background: Tolerance and dependence to anti-nociceptive effect of morphine restricted its use. Nowadays co-administration of morphine and other drugs suggests diminishing this tolerance. Baclofen is one of the drugs that may be beneficial in the attenuation of tolerance to morphine. Studies have shown that changes in transient receptor potential vanilloid type 1 (TRPV-1) expression during admi...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید