Upper gastrointestinal (GI) bleeding is defined as bleeding proximal to the ligament of Treitz. The most important aspect of management of GI bleeding is to locate the site and cause of bleeding. The aim of the study is to find out the common etiology, presentation and management, including the role of upper GI endoscopy. Recent advances have meant that endoscopic hemostatic methods are now ass...

Inflammatory Bowel Disease (IBD) is a term used to describe group of complex disorders the gastrointestinal (GI) tract. IBDs include two main forms: Crohn’s (CD) and Ulcerative Colitis (UC), which share similar clinical symptoms but differ in anatomical distribution inflammatory lesions. The etiology undetermined. Several hypotheses suggest that result from an abnormal immune response against e...

Overview GI obstructions are a common cause of vomiting in patients seen in clinical practice. Causes of anatomic obstruction include foreign bodies (linear or nonlinear), pyloroantral hypertrophic disease, polyps, intussusception, intramural masses (neoplasia, granulomatous enteritis, phycomycosis, satrictures, hematoma), and extramural compression (adhesions, strangulation, volvulus). Functio...

BACKGROUND Gastrointestinal (GI) motility disorders are highly prevalent in populations worldwide and the development of effective and safe drug treatments for GI motility disorders has proven challenging. In this study, taking advantage of the transparency of larval zebrafish, we developed a novel zebrafish GI motility model for drug screening and efficacy assessment. METHODS Zebrafish at 5 ...

Visceral pain is prevalent and is a leading cause of health care utilization worldwide.1 Unexplained abdominal pain is the sixth most common cause of hospital admission for any cause in women and the tenth most common cause in men.2 In the United Kingdom, it has been estimated that nonspecific abdominal pain costs the economy in excess of £100 million per annum.3 Functional abdominal pain (FAP)...

PURPOSE The purpose of this study was to estimate the incidence of occult gastrointestinal (GI) primary tumours in patients with metastatic cancer of uncertain primary origin and evaluate their influence on treatments and overall survival (OS). MATERIALS AND METHODS We used population heath data from Manitoba, Canada to identify all patients initially diagnosed with metastatic cancer between ...