Listeria monocytogenes is a gram-positive bacterial pathogen that multiplies in the cytosol of host cells and spreads directly from cell to cell. During cell-to-cell spread, bacteria become temporarily confined to secondary vacuoles. The broad-range phospholipase C (PC-PLC) of L. monocytogenes contributes to bacterial escape from secondary vacuoles. PC-PLC requires cleavage of an N-terminal pro...

An analytic robust model is developed for estimating GDL thermal conductivity. The model considers PTFE addition to the GDL. Thermal conductivity of MPL is accurately measured in a compression range of 2e14 bar. Effect of thermal conductivity on PTFE, MPL, and compression is considered. Thermal contact resistances between GDL and MPL/iron surface are measured. a r t i c l e i n f o

OTT was first identified as part of the recurrent t(1;22) translocation in acute megakaryoblastic leukemia (AMKL) and was called OTT for “one twenty-two.” OTT1 is also known as RNA binding motif protein 15 (RBM15). Like other RNA binding motif proteins, RBM15 contains RNA recognition motifs (RRMs), 3 in total, which can bind to RNA and, at least for some RRMs, may also bind to DNA. Lifelong mai...

Somatic mutations in the calreticulin (CALR) gene were recently discovered in patients with sporadic essential thrombocythemia (ET) and primary myelofibrosis (PMF) lacking JAK2 and MPL mutations. We studied CALR mutation status in familial cases of myeloproliferative neoplasm. In a cohort of 127 patients, CALR indels were identified in 6 of 55 (11%) subjects with ET and in 6 of 20 (30%) with PM...

Dysregulated Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling due to activation of tyrosine kinases is a common feature of myeloid malignancies. Here we report the first human disease-related mutations in the adaptor protein LNK, a negative regulator of JAK-STAT signaling, in 2 patients with JAK2 V617F-negative myeloproliferative neoplasms (MPNs). One patient e...

Introduction. Haplotype JAK2 46/1 is associated with more frequent development of Ph-negative myeloproliferative neoplasms (MPN) and an increased detection rate the V617F mutation. At same time, molecular mechanisms such associations remain unclear. Previously, there were no studies regional, age gender aspects predictive value carriage haplotype, which could assess this relationship in some ob...

Administration of 5-fluorouracil (5-FU) to mice results in a marked increase in the level of circulating platelets in 10 days. Mice lacking Mpl, the receptor for thrombopoietin (TPO), are thrombocytopenic. To gain insight into the mechanism by which 5-FU produces such a substantial stimulation of platelet production, this study investigated whether 5-FU (150 mg/kg) produced thrombocytosis in c-...

Abstract The idea of preference reversal and construction of preference is not new to literature in decision making. Indeed, several theories have been developed to explain it. (Lichtenstein and Slovic, 2006). The present paper considers heuristics activated in different elicitation procedures applied in time preference research. I show that activation of these rules in correspondence with diff...

Background: Clonal hematopoiesis (CH) is frequently incidentally found in liquid biopsy and may reveal a risk situation for developing myeloid malignancy or uncover occult hematologic disease. Material methods: Adult patients with treatment-naïve pre-treated advanced solid cancer enrolled the Gustave Roussy Cancer Profiling study (STING, NCT04932525) underwent at least one next-generation seque...

Developments of the porous transport layers (PTLs) in recent years resulted significant performance improvements polymer electrolyte water electrolyzers (PEWEs). One milestones material design was integration a microporous layer (MPL) on sintered titanium PTLs. Utilizing high-resolution neutron imaging, and gas distribution multi-layered media (ML-PTL) probed at various current densities (up to...