Combination of asenapine with valproic acid received regulatory approval for acute treatment of schizophrenia and maniac episodes of bipolar disorders. A simple LC-MS/MS method was developed and validated for simultaneous quantification of asenapine and valproic acid in human plasma. Internal standards were added to 300 μL of plasma sample prior to liquid-liquid extraction using methyl tertiary...

MTBE is found in water supplies used for drinking and other purposes. These experiments follow up on earlier reports of reproductive tract alterations in male mice exposed orally to MTBE and explored oxidative stress as a mode of action. CD-1 mice were gavaged with 400-2000 mg/kg MTBE on days 1, 3, and 5, injected i.p. with hCG (2.5 IU/g) on day 6, and necropsied on day 7. No effect was seen in...

A magnetoresistive biosensing platform based on a single magnetic tunnel junction (MTJ) scanning probe and DNA microarrays labeled with magnetic particles has been developed to provide an inexpensive, sensitive and reliable detection of DNA. The biosensing platform was demonstrated on a DNA microarray assay for quantifying bacteria capable of degrading methyl tertiary butyl ether (MTBE), where ...

Nowadays a growing demand for green chemicals and cleantech solutions is motivating the industry to strive for biobased building blocks. We have identified the tertiary carbon atom-containing 2-hydroxyisobutyric acid (2-HIBA) as an interesting building block for polymer synthesis. Starting from this carboxylic acid, practically all compounds possessing the isobutane structure are accessible by ...

REY area has been located in Tehran Province and several archaeological ruins of this area indicate that the settlement in this area has been started since several thousand years ago. In this paper, the main investigation items consist of analysis of oil components and groundwater quality inside the wells. By finding the contents of oil in the well, it is possible to find out the pollution sour...

A number of transportation fuels can be produced from renewable resources. The major fractions of lignocellulosic biomass, cellulose and hemicellulose, can be broken down into sugars that can be fermented into ethanol. Biomass can also be gasified to a mixture of carbon monoxide and hydrogen for catalytic conversion into methanol. Algae could consume carbon dioxide from power plants and other s...

Abstract: This paper reports the results of an FT-IR and NIR study of N-methylformamide in carbon tetrachloride solution in presence of ethers as the O-electron donors, i.e., diethyl ether (DEE), diisopropyl ether (DiPE), methyl t-butyl ether (MtBE), dibutyl ether (DBE), dipentyl ether (DPE), tetrahydrofuran (THF) and tetrahydropyran (THP). The spectroscopic characteristics of the N–H···O hydro...