The most common source of musculoskeletal algia is the myofascial pain syndrome (MPS), its occurrence is related to excessive involuntary muscle contraction and is characterized by hardened regions. Myofascial trigger points (MTP) are hypersensitive nodules that refer pain spontaneously or under mechanical stimuli, present in 37 % of men and 65 % women, and may be classified as: active, latent,...

Mitochondrial trifunctional protein (MTP) is a recently identified enzyme involved in mitochondrial b -oxidation, harboring long-chain enoyl-CoA hydratase, long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) and long-chain 3-ketothiolase activity. A deficiency of this protein is associated with impaired oxidation of long-chain fatty acids which can lead to sudden infant death. Furthermore, it is...

The year 2001 signaled the end of Japan’s Micromachine Technology Project (MTP), and the beginning of a new era in Japanese development of microand nano-technologies and systems. When launched in 1991, the MTP initiative influenced the landscape of MEMS and microsystems technologies not only in Japan but in the rest of the world as well. One of the most powerful industrial nations in the world ...

Mutations in microsomal triglyceride transfer protein (MTP) cause abetalipoproteinemia (ABL), characterized by the absence of plasma apoB-containing lipoproteins. In this study, we characterized the effects of various MTP missense mutations found in ABL patients with respect to their expression, subcellular location, and interaction with protein disulfide isomerase (PDI). In addition, we charac...

In our earlier paper ([AKT1]), by interpreting the formal transformation to the Airy equation near a simple turning point as the symbol of a microdifferential operator, we derived the Voros connection formula or, equivalently, the discontinuity function of a Borel transformed WKB solution at its movable singularities. In this paper we extend this approach to the two turning points problem; by c...

The first metatarsophalangeal (MTP) joint is a critical component for normal walking. The present study aimed to investigate the effects of restricting the flexion-extension motion of the first MTP joint on human walking gait. Ten male participants were recruited to perform walking trials under barefoot (BF) and the first MTP joint constraint (FMJC) conditions, respectively. The results showed ...

Abetalipoproteinemia (ABL) is a rare autosomal disorder characterized by extremely low levels of plasma lipids and apolipoprotein B (apoB) with a variable phenotype. Mutations in the MTP gene encoding the microsomal triglyceride transfer protein (MTP) cause the disease. A five-month-old boy, born from consanguineous parents, with chronic diarrhea and severe malnutrition had extremely low plasma...

A higher throughput method of screening for the inhibition of recombinant CYP2D6 using a microtiter plate (MTP) assay was evaluated using 62 new chemical entities and compared to data from the dextromethorphan O-demethylase assay in human liver microsomes (HLM). The IC50 values for the two assays closely matched for 53 compounds (85%). Six of the variant nine compounds had higher IC50 values wi...

An estimated 40% of the US population have foot problems.Of all patients aged over 50 years, 2.5% report degenerative arthritis of the first metatarsophalangeal (MTP) joint, termed 'hallux rigidus'. First MTP osteoarthritis is the most common arthritic condition in the foot.Progression of great toe arthritis is associated with pain and loss of motion. Non-surgical intervention begins with shoe ...

PURPOSE To review the outcome of arthrodesis of the hallux metatarsophalangeal (MTP) joint in 23 patients. METHODS Records of 9 men and 14 women aged 27 to 88 (mean, 57) years who underwent arthrodesis of the hallux MTP joint using an intramedullary device and an intra-osseous device were reviewed. Indications for surgery were severe hallux valgus (n=15), hallux rigidus (n=6) and rheumatoid a...