The objective of the present study was to develop n-propyl gallate-loaded solid lipid nanoparticles (PG-SLNs) in a hydrogel (HG) formulation using Transcutol-P (TC-P) as permeation enhancer. Modified solvent injection technique applied produce optimized PG-SLNs via Quality by Design approach and central composite design. vitro mucoadhesion, scavenging activity, drug release, studies PG from PG-...

Traditional oral dosage forms prone to first pass metabolism and degra­dation due enzymes but mucoadhesive form able bypass related degradation. It also offers more patient compliance without risk of chocking in case paediatric geriatric patients. Buccal mucosa is considered as a convenient easily accessible site for the drug administration both local systemic delivery. Mucoadhesion process inv...

Whey protein is fortified into beverages to provide functional benefits, however, these are considered mouthdrying. To date whey derived mouthdrying has not been quantified using a ‘physical measure’ in parallel with rated perception. Saliva flow could also relate mouthdrying, however this previously tested as an intervention. Accordingly, volunteers (n = 40) different and the sensory profile w...

Besides viability protection, a sufficiently prolonged gastrointestinal retention of probiotics has emerged as critically important in improving the functional effectiveness delivery these microorganisms. In this work, we formulated pure, resistant starch-reinforced and chitosan-coated alginate microparticles using an electrospray technique evaluated their performance mucoadhesive probiotic for...

Aim: The aim of the work was to explore mucoadhesive properties Mastic gum by involving it in microspheres with Amoxicillin Trihydrate as a model drug. Using Carbopol-934P and varying amounts gum. Methods: 9 interpretations were made using Design expert software. A central composite design applied test impact independent variables (Carbopol-934P mastic levels) on drug released at 10h strength r...

Emerging antibiotic resistance in pathogens has posed considerable challenges to explore and examine the natural antimicrobials (NAMs). Due labile nature of NAMs, nano-delivery systems (NDS) are required protect them from physiological degradation allow controlled delivery targeted site infection. In this study, corona modified NDS were developed using bovine serum albumin (BSA) on a chitosan c...

Buccal matrices represent a widely accepted dosage form permitting convenient, easy, reliable drug administration and reducing errors. The aim of this study was the development mucoadhesive buccal for propranolol in children. Matrices were obtained by freeze-drying loaded polymeric solutions based on gum tragacanth (GT), pectin (PEC), hydroxypropylmethylcellulose (HPMC), sodium hyaluronate (HA)...

In the present study, luteolin (LTN)-encapsulated chitosan (CS) coated nanostructured lipid carriers (NLCs) were formulated using melt emulsification ultrasonication technique. NLCs optimized by 33-QbD approach for improved in vitro efficacy against breast cancer cell lines. The LTN-CS-NLCs successfully characterized different and ex vivo experiments as well evaluated cytotoxicity MDA-MB-231 MC...