Mucus and its gel-forming glycoprotein component, mucin, are thought to protect the gastrointestinal tract from enteric pathogens by inhibiting their attachment to enterocytes. In this study, we investigated interactions between Yersinia enterocolitica (isogenic strains of virulent and nonvirulent organisms) and crude mucus, highly purified mucin, and brush border membranes (BBMs) isolated from...

A novel glycosulphatase has been purified from a mucus glycopeptide-degrading Prevotella from the colon. The purified enzyme removed inorganic [35S]sulphate from 35S-labelled native rat gastric mucus glycoprotein. Desulphation of mucus glycoprotein was initially rapid (19% complete after 10 min) but then plateaued, reaching only 33% after 3 h. Crude periplasmic extracts could remove 79% of the ...

Accumulation of thick, sticky mucus is a hallmark of the genetic disease cystic fibrosis (CF) and has a central role in CF pathophysiology. Mutations in the CF transmembrane regulator (CFTR) ion channel are known to result in abnormally thick and sticky mucus; however, why mucus accumulates in CF is still not completely understood. In this issue of the JCI, Garcia and colleagues show that mucin...

Partial or total obstruction of an endotracheal tube (ETT) by mucus can cause severe respiratory distress, hypoxemia, or death. Signs of an obstructed ETT include increased ventilation pressure, changes in the ventilator graphics, S(pO(2)) decrease, and cardiovascular changes. We present 3 patients whose ETTs were partially obstructed by mucus. In each case the patient displayed adverse effects...

Introduction Nasal mucus is the first line defense barrier against various allergens. Proteins are functional molecules in mucus and have different roles especially in immune response. Apolipoproteins are plasma proteins that are mainly involved in lipid metabolism, but also have anti-inflammatory properties. The role of this study was to identify apolipoproteins in nasal mucus of allergic rhin...

Twelve healthy and not pregnant local cows, aged 3-6 years, 1-3 parity. The cows were synchronized using the PGF2α of 5 ml/cow intramuscularly, twice at 11 days intervals. Estrus detection based on scoring van Eerdenburg was conducted 24 hours after second prostaglandin injection three times daily for days. changes in cervical dilatation observed 0, 6, 12 from onset estrus. result showed that 8...

Extracts and preparations made from the animal origin were used extensively in folk and modern medicine for treating many human diseases. In the present study efforts have been made to find the antimicrobial effect of the mucus of two bottom dwelling fresh water fishes namely, Channa punctatus and Cirrhinus mrigala. Fish mucus were tested against ten pathogenic bacteria such as Escherichia coli...

Airway mucus hypersecretion and secretion retention can result from inflammation, irritation, stimulation, or mucus-producing tumors. Secretion clearance can be furthered hampered by ciliary dysfunction and by weakness or restrictive lung disease, leading to an ineffective cough. There are a number of different mucoactive medications that have been used to reduce hypersecretion, make secretions...

The effects of S-carboxymethylcysteine on tracheal mucus velocity were assessed in a double blind crossover study between 2 grams S-carboxymethylcysteine and placebo. Subjects included six healthy non-smokers, eight smokers with small airway disease and chronic simple bronchitis, and eight subjects with chronic obstructive bronchitis. Tracheal mucus velocity was measured prior to and two and th...

embryo transfer and its related factors received little clinical attention and had been, until recently, the most inefficient step in in-vitro fertilization (ivf). factors which appear to influence implantation rates are: contamination of the catheter tip with cervical bacteria, stimulation of uterine contractions during the procedure, the type of catheter, ultrasound guidance during the transf...