Steroidogenic factor-1 (SF-1) (Ad4BP, NR5A1) is a nuclear receptor that regulates many aspects of adrenal and reproductive development and function. Consequently, deletion of the gene (Nr5a1) encoding Sf-1 in XY mice results in impaired adrenal development, complete testicular dysgenesis with Mullerian structures, and female external genitalia. Initial efforts to identify NR5A1 changes in human...

Introduction: Breast cancer is the second most common in premenopause age, has a better outcome now. Increasing early detection rates and effectiveness of adjuvant chemotherapy treatments are factors that influence prognosis dan survival rate. However, treatment can lead to ovarian dysfunction resulting decreased quality life.Case: A-29-year-old woman with breast received regimen Docetaxel, Dox...

Abstract Background Persistent Mullerian Duct Syndrome (PMDS) is a type of pseudo-hermaphroditism occurring in males internally due to failure the Anti Hormone (AMH)-dependent sex differentiation pathway. Due absent (AMH), adult male has both Wolffian and duct derivatives. Considering limited information available existing literature, malignant transformation PMDS rarely been reported. Case Pre...

Heightened mammalian target of rapamycin complex 1 (mTORC1) activity by genetic deletion of its direct inhibitor, Tsc1, is associated with aberrant development and dysfunction of the female reproductive tract in mice. Here, we compared the phenotypes of mice with conditional deletion of Tsc1 in the female reproductive tract by either progesterone receptor (PR)-Cre (Tsc1(PR(d/d))), which inactiv...

BACKGROUND The sertoli cells in the testis create unique and safe environment to protect seminiferous tubules from auto antigens and invading pathogens. These cells produce the survival factor of the blood-testis barrier and produce special materials such as androgen binding proteins and contribute to the coordinated action of spermatogenesis. Given that the sertoli cells play an essential role...

Aim: This study was conducted to explore the effect of serum anti-Mullerian hormone (AMH) level on in vitro fertilization (IVF) cycle outcomes. Material and Methods: A total 142 patients included this study, were divided into three groups according their AMH levels as Group 1: 5-10 ng/ml (n=108), 2: 10-15 (n=20), 3: >15 (n=14). Demographic characteristics recorded. The duration infertili...