A green methodology for the development of the synthesis of dihydropyrimidinones via a clean multi-component Biginelli reaction by using cyclohexane-1,4-diyl bis (hydrogen sulfate) (CDBH) as an effective catalyst in water and solvent-free conditions was reported. This sulfonated catalyst is an efficient and environmentally benign homogeneous catalysts which characterized by using different tech...

The Multilingual Central Repository (MCR) is based on the design of the EuroWordNet database. The MCR holds WordNets in various languages (English, Spanish, Italian, Catalan and Basque), which are interconnected via an Inter-LingualIndex (ILI). In addition, the MCR holds a number of ontologies and domain labels related to all concepts. This paper describes the integration and evaluation of the ...

The aim of the study was to develop a multiplex assay for rapid detection of mcr-1, mcr-2, and mcr-3, a group of genes of conferring resistance to colistin mediated by plasmid in Enterobacteriaceae. A SYBR Green based real-time PCR assay has been designed to detect the mcr genes, and applied to cultured bacteria, feces and soil samples. All three mcr genes could be detected with a lower limit o...

facile and versatile procedures have been explored for the synthesis of tetrahydropyridines and 2,3-dihydroquinazolin-4(1h)-ones. these protocols employ the one-pot multi-component condensation of arylaldehydes and aromatic amines with β-keto esters and isatoic anhydride in chloroacetic acid, respectively. the reactions proceeded smoothly to generate the corresponding products in high yield. we...

In this paper the problem of selecting optimal paths in a MCMI (Multi-Channel Multi-Interface) WMN (Wireless Mesh Network) is considered. The WMNs are characterized by high dynamic range of the received signal level, especially in the indoor environment. To improve the existing routing metrics and track fast changes that occur in the link state, a corresponding parameter based on the received s...

Methyl-coenzyme M reductase (MCR) catalyzes the terminal step in the formation of biological methane from methyl-coenzyme M (Me-SCoM) and coenzyme B (CoBSH). The active site in MCR contains a Ni-F(430) cofactor, which can exist in different oxidation states. The catalytic mechanism of methane formation has remained elusive despite intense spectroscopic and theoretical investigations. On the bas...

In late 2015, the first example of a transferrable polymyxin resistance mechanism in Gram-negative pathogens, MCR-1, was reported. Since that report, MCR-1 has been described to occur in many Gram-negative pathogens, and the mechanism of MCR-1-mediated resistance was rapidly determined: an ethanolamine is attached to lipid A phosphate groups, rendering the membrane more electropositive and repe...

Metabolic clearance (MCR) and production rates (PR) of human thyrotropin (hTSH) were determined by the constant infusion to equilibrium method 57 times in 55 patients. 16 control patients had a mean hTSH MCR of 50.7 ml/min. The mean hTSH MCR was significantly (P < 0.02) higher in 19 euthyroid men (51.6 ml/min) than in 12 euthyroid women (43.0 ml/min), but this apparent sex difference disappeare...

a method based on the genetic algorithm (ga) was developed to study the phase behavior of multicomponent and multiphase systems. upon application of the ga to the thermodynamic models which are commonly used to study the vle, vlle and lle phase equilibria, the physically meaningful values for the binary interaction parameters (bip) of the models were obtained. using the method proposed in this ...