Acute liver failure (ALF) is a progressive life-threatening condition characterized by hepatic dysfunction with coagulopathy and hepatic encephalopathy (HE) that evolves over a few days or weeks. Besides development of HE, ALF results in development of multi-organ failure (MOF), and is still associated with a ~40% mortality risk depending on the etiology and severity of liver injury. The progno...

Introduction: There have been several reports on levels of GST and thiol status in hepatocellular damage. Very few comparative studies are available to know the levels of GST and thiols in various disorders causing hepatocellular damage. Current study was undertaken to know serum GST activity and total thiols status in patients with various disorders causing liver damage. Subjects and methods: ...

INTRODUCTION Severe mixed β-blocker and calcium channel blocker intoxication presents a significant risk for patient mortality. Although treatment is well-established, it sporadically fails to support the patient through massive overdoses, thus requiring non-conventional treatments. We report the use of extra-corporeal life support in a patient with refractory hemodynamic impairment due to mult...

Cerebral malaria is a clinical manifestation of the brain during Plasmodium falciparum infection, which may lead to fatal outcomes if left unattended or delayed in therapeutic management. It is often accompanied by multi-organ complications such as renal failure, respiratory distress, jaundice, severe anemia etc., further raising the degree of mortality. Over the years, the management of severe...

Hemophagocytic syndrome is a potentially fatal disorder. It is being increasingly reported but remained under-recognized in dengue. Most reported cases were in association with plasma leakage and shock but multi-organ impairment was also observed. We describe the time-lines of 6 cases of confirmed dengue with varying severities of hemophagocytosis. All had persistent fever, cytopenia and elevat...

INTRODUCTION Thyroid storm is an endocrinological emergency caused by an exacerbation of the hyperthyroid state and is characterized by multi organ dysfunction. Liver dysfunction or injury predominantly of a cholestatic type is one of the atypical manifestations of thyroid storm and has been previously described in literature. However, there have been few published case reports among African pa...

This Virulence special focus highlights the emerging critical role of endothelial activation and dysfunction in the pathogenesis of infectious diseases and associated clinical outcomes. Infectious disease investigators might ask why endothelial biology should be of interest to them. We hope that this special focus will make the research community think otherwise. The endothelium is comprised of...