Data envelopment analysis (DEA) is a common technique in measuring the relative efficiency of a set of decision making units (DMUs) with multiple inputs and multiple outputs. ‎‎Standard DEA models are ‎‎quite limited models‎, ‎in the sense that they do not consider a DMU ‎‎at different times‎. ‎To resolve this problem‎, ‎DEA models with dynamic ‎‎structures have been proposed‎.‎In a recent pape...

The lane change maneuver is among the most popular driving behaviors. It is also the basic element of important maneuvers like overtaking maneuver. Therefore, it is chosen as the focus of this study and novel multi-input multi-output adaptive neuro-fuzzy inference system models (MANFIS) are proposed for this behavior. These models are able to simulate and predict the future behavior of a Dri...

The extracellular space of the brain contains gamma-aminobutyric acid (GABA) that activates extrasynaptic GABA(A) receptors mediating tonic inhibition. The source of this GABA is uncertain: it could be overspill of vesicular release, non-vesicular leakage, reverse transport, dying cells or glia. Using a novel approach, we simultaneously measured phasic and tonic inhibitory currents and assessed...

Conflicting opinions exist as to whether the phasic (reflex) component alone or both the phasic and tonic (adaptive) components of the accommodation and vergence systems drive accommodative vergence and vergence accommodation crosslinks. In this study the dissociated phoria to a 2 D target was measured before and after accommodative adaptation to discriminate the two possibilities. Results show...

Phasic activation of dopaminergic neurons is associated with reward-predicting cues and supports learning during behavioral adaptation. While noncontingent activation of dopaminergic neurons in the ventral tegmental are (VTA) is sufficient for passive behavioral conditioning, it remains unknown whether the phasic dopaminergic signal is truly reinforcing. In this study, we first targeted the exp...

Phasic and tonic inhibitions are two types of inhibitory activities involved in inhibitory processing in the CNS. In the spinal cord dorsal horn, phasic inhibition is mediated by both GABAergic and glycinergic inhibitory postsynaptic currents. In contrast to phasic inhibitory currents, using patch-clamp recording technique on spinal cord slices prepared from adult mice we revealed that tonic in...

In the present study, we investigated effects of phasic alerting on visual attention in a partial report task, in which half of the displays were preceded by an auditory warning cue. Based on the computational Theory of Visual Attention (TVA), we estimated parameters of spatial and non-spatial aspects of visual attention and measured event-related lateralizations (ERLs) over visual processing a...

Motor neurons are matched to their target muscles, often forming separate phasic and tonic systems as in the abdomen of crayfish where they are used for rapid escape and slow postural movements, respectively. To assess the role of motor neuron and muscle fiber in forming synapses we attempted a mismatch experiment by allotransplanting a phasic nerve attached to its ganglion to a denervated toni...

Human colonic circular muscle produces spontaneous phasic contractions that are reduced in ulcerative colitis. How the spontaneous phasic contractions develop and why they decrease in ulcerative colitis are not known. We found that spontaneous phasic contractions of normal sigmoid circular muscle strips were significantly reduced by 90-min incubation with tetrodotoxin (10(-5) M), which blocked ...

ABSTRACT Nephron endowment, defined during the fetal period, dictates renal and related cardiovascular health throughout life. We show here that, despite its negative effects on kidney growth, genetic increase of GDNF prolongs nephrogenic program beyond normal cessation. Multi-stage mechanistic analysis revealed that excess maintains nephron progenitors nephrogenesis through increased expressio...