The temperature-sensitive mutation prp20-1 of Saccharomyces cerevisiae exhibits a pleiotropic phenotype associated with a general failure to maintain a proper organization of the nucleus. Its mammalian homolog, RCC1, is not only reported to be involved in the negative control of chromosome condensation but is also believed to assist in the coupling of DNA replication to the entry into mitosis. ...

Biochemical and genetic findings accumulated over the past decade have established that the condensation of eukaryotic DNA in chromatin functions not only to constrain the genome within the boundaries of the cell nucleus but also to suppress gene activity in a general manner. This genetic repression extends from the level of the nucleosome, the primary unit of chromatin organization, where coil...

Dense multicomponent systems with macromolecules and small solutes attract a broad research interest as they mimic the molecularly crowded cellular interiors. The additives can condense and align the macromolecules, but they do not change the degree of covalent polymerization. We chose a lyotropic chromonic liquid crystal with reversibly and non-covalently assembled aggregates as a much softer ...

Phosphonate derivatives were prepared using multicomponent reactions of dialkyl acetylenedicarboxylate with 4-hydroxycumarine in the presence of trimethyl or triphenyl phosphite in good yields.

The high-order ambiguity function (HAF) was introduced for the estimation of polynomial-phase signals (PPS) embedded in noise. Since the HAF is a nonlinear operator, it suffers from noise-masking effects and from the appearance of undesired cross terms and, possibly, spurious harmonics in the presence of multicomponent (mc) signals. The product HAF (PHAF) was then proposed as a way to improve t...

Hydrogels provide mechanical support and a hydrated environment that offer good cytocompatibility and controlled release of molecules, and myriad hydrogels thus have been studied for biomedical applications. In the past few decades, research in these areas has shifted increasingly to multicomponent hydrogels that better capture the multifunctional nature of native biological environments and th...

This review identifies evidence-based psychological treatments (EBTs) for reducing distress, and improving well-being, of family members caring for an older relative with significant cognitive and/or physical impairment. Three categories of psychologically derived treatments met EBT criteria: psychoeducational programs (N = 14 studies), psychotherapy (N = 3 studies), and multicomponent interven...

Multicomponent data usually are not processed with specifically designed procedures but with procedures analogous to those used for single-component data. In isotropic media, the vertical and horizontal components of the data commonly are taken as proxies for the Pand S-wave modes, which are imaged independently with the acoustic wave equations. This procedure works only if the vertical and hor...

Multicomponent pharmaceutical solids is a hot topic that brings together the knowledge of crystal engineering and need to achieve novel effective drugs at lower costs for industry [...]