Ancient and modern 183 varieties of winter 23 spring types development bread wheat (Triticum aestivum L.) selected Ukrainian state institutions private companies are characterized by alleles Ppd-D1, Ppd-B1, Ppd-A1 genes. Allele-specific molecular markers, proposed in the scientific literature, were used to identify carriers Ppd-D1a, Ppd-D1b, Ppd-D1c, Ppd-D1d, Ppd-B1a, Ppd-B1c, Ppd-A1b alleles. ...

Numerous genetic polymorphisms and clinical laboratory parameters are associated with ischemic stroke (IS). However, the results of such studies have frequently been inconsistent. The aim present study was to evaluate associations between that influence risk IS in a Chinese Han population. Clinical were measured by an automatic biochemical analyzer. Genotype allele frequencies angiotensin‑conve...

To identify a fast and sensitive method for screening for mutations in patients with imatinib- resistant chronic myeloid leukemia (CML), we compared allele specific oligonucleotide- polymerase chain reaction (ASO-PCR) assay with conventional direct sequencing. Among the 68 imatinib resistant CML patients studied, 18 amino acid substitutions were detected in 44 patients by two assays. The sensit...

Background: Aggressive behavior (AB) represents an important social problem, which results in significant costs for the society. A role developing aggression is suggested to be mediated by molecular mechanisms related functioning of oxytocin (OXTR) and arginine vasopressin receptor (AVPR1B) genes involved regulation behavior. On other hand, a specificity environmental factors affecting individu...

BACKGROUND Recently, it has become evident that RNA editing-related changes are important in the modulation of neuronal information processing. Alternatively edited transcripts, when meagerly present, are hard to detect. Significant functional consequences may result, however, from small differences in editing efficiency. Moreover, it is difficult to evaluate the ratio of edited transcripts. Th...

  Background and Objective: The outcome of hepatitis B virus (HBV) infection may be influenced by host factors like Human Leukocyte Antigen (HLA). We have investigated HLA-A and DRB1 alleles in patients with persistent hepatitis B infection compared to subjects who had spontaneously recovered from HBV infection. To complete the findings of this study we performed another survey in certain HLA ...

Genotyping of thiopurine S-methyltransferase (TPMT) is recommended for predicting the adverse drug response of thiopurines. In the current study, a novel version of allele-specific PCR (AS-PCR), termed competitive real-time fluorescent AS-PCR (CRAS-PCR) was developed to analyze the TPMT*2 genotype in ethnic Chinese. This technique simultaneously uses wild-type and mutant allele-specific scorpio...