It has been shown that acute administration of interleukin-1 (IL-1 ) to rats elicits a transitory increase in plasma ACTH and corticosterone (B) levels. To investigate the effects of chronic administration of IL-1 on plasma ACTH and B levels, in the present study rats were equipped with Alzet osmotic minipumps loaded with either IL-1 (delivery rate 0.5, 2.0, or 4.0 fig/ 24 h, ip, for 1 week) or...

It has been shown that acute administration of interleukin-1 (IL-1 ) to rats elicits a transitory increase in plasma ACTH and corticosterone (B) levels. To investigate the effects of chronic administration of IL-1 on plasma ACTH and B levels, in the present study rats were equipped with Alzet osmotic minipumps loaded with either IL-1 (delivery rate 0.5, 2.0, or 4.0 fig/ 24 h, ip, for 1 week) or...

the observations that DCs are recruited to the lamina propria of the small intestine after bacterial infection, and the number of DCs recruited depends on the pathoMaria Rescigno1,3 and Persephone Borrow2,3 1 Department of Bioscience and Biotechnology U3 University of Milano-Bicocca genicity of the microorganisms encountered. In line with Piazza della Scienza, 2 this, it has been shown that bac...

The in vitro pharmacological profile of a novel small molecule corticotropin-releasing factor 1 (CRF1) receptor antagonist, ( )N-[2-methyl-4-methoxyphenyl]-1-(1-(methoxymethyl)propyl)6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine (SN003), and the characteristics of its radioligand ([H]SN003) are described. SN003 has high affinity and selectivity for CRF1 receptors expressed in rat cortex, pit...

ion where each level .'is a decomposition of the higher one. In WinWin, the process --actions are situated and do not have hierarchical levels of decomposition. The problem of scalability arises from the complexity of managing the artifacts. win conditions, conflicts, and points of agreement that result from stakeholder actions as opposed to planning and execution of complex process instances. ...

The value of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, in deriving novel diagnostic and therapeutic input has been subject to recent debate. This study is the first to report a disseminated distribution of plaques including cranial nerves, prior to or at early stages of disease in murine adoptive transfer EAE, irrespective of the development of clin...