The aim of this study was to analyse various gene expression profiles of muscle tissue during normoxia, ischaemia and after reperfusion in human muscle free flaps, to gain an understanding of the occurring regulatory, inflammatory and apoptotic processes on a cellular and molecular basis. Eleven Caucasian patients with soft tissue defects needing coverage with microsurgical free muscle flaps we...

The advantages of breast reconstruction using the deep inferior epigastric perforator (DIEP) flap and the muscle-sparing free transverse rectus abdominis musculocutaneous (TRAM) flap (MS-2) are well recognized. Both techniques optimize abdominal function by maintaining the vascularity, innervation, and continuity of the rectus abdominis muscle. The purpose of this study was to compare these two...

OBJECTIVE To evaluate prospectively the feasibility and utility of adding a cervical extension to the standard deltopectoral flap. We postulated that this cervicodeltopectoral (CDP) flap will allow for single-stage reconstruction of large defects of the anterolateral face and neck. METHODS As is the case with the deltopectoral flap, the CDP flap is based on the perforating branches of the int...

Axillary hidradenitis suppurativa is a chronic recurrent disorder characterized by abscessing inflammation, fistulating sinus tracts, and scarring. This is not only a medical disease, but also a complicated problem necessitating surgical intervention. While various management strategies have been reported, the results are frequently unsatisfactory. Primary closure of the defect after radical ex...

SUMMARY Posttraumatic upper or lower limb salvage is still challenging. Under difficult situations in which only one vessel supplies the hand or foot, free microvascular reconstruction might damage not only the transferred tissue but also the terminal hand or foot. Two cases of incomplete amputation of the unilateral forearm with large radius bone and soft tissue loss were reconstructed using a...

Developments in microsurgical techniques and instruments have enabled the high success rate of microvascular tissue transfers. Initially, the survival of a free flap is dependent on its vascular pedicle, and the failure of flaps generally occurs within seven days of surgery. Several experimental studies have shown that pedicles can be ligated 5 to 10 days after the operation. Hence, at that tim...

Patients with intracranial aneurysm(s) of the carotid artery territory, treated with pterional craniotomy, were prospectively and randomly addressed to one layer flap (n = 36) or myocutaneous (MC) versus two layers' dieresis (n = 32) or interfascial (IF). The study protocol included the patient's sex, age, area of craniotomy, time of flap dieresis and synthesis, time of bone dieresis and synthe...

Reconstruction of a composite maxillary defect is frequently performed with a fibular osteocutaneous free flap to address both the bony and mucosal defect. If during the harvest of the fibula a distal skin perforator is not present due to vascular variations, reconstruction can potentially be done using the soleus muscle for filling of the palatal mucosal defect. An additional challenge arises ...

University of Manitoba, Winnipeg, Manitoba Correspondence: Dr Edward W Buchel, University of Manitoba, GC 404, 820 Sherbrook Street, Winnipeg, Manitoba R3A 1R9. E-mail [email protected] The majority of autologous free flap breast reconstruction uses tissue from the lower anterior abdominal wall. Traditionally, this involved harvesting the entire ipsilateral or bilateral rectus abdominus muscles...