Background: During the aging process, muscle atrophy and neuromuscular junction remodeling are inevitable. The present study aimed to clarify whether low-intensity aerobic exercise along with limb blood-flow restriction (BFR) could improve aging-induced muscle atrophy and nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction.Methods: Forty-eight male Wistar rats, aged 23–24 m...

Skeletal muscles display a remarkable diversity in their arrangement of fibers into fascicles and in their patterns of innervation, depending on functional requirements and species differences. Most human muscle fascicles, despite their great length, consist of fibers that extend continuously from one tendon to the other with a single nerve endplate band. Other mammalian muscles have multiple e...

Adult transgenic mice with muscle-specific overexpression of insulin-like growth factor (IGF)-I have enlarged skeletal muscles. In this study, we; 1) characterized the development of muscle hypertrophy with respect to fiber type, age, and sex; 2) determined the primary anabolic process responsible for development of hypertrophy; and 3) identified secondary effects of muscle hypertrophy on body ...

We previously reported that leukocyte specific β2 integrins contribute to hypertrophy after muscle overload in mice. Because intercellular adhesion molecule-1 (ICAM-1) is an important ligand for β2 integrins, we examined ICAM-1 expression by murine skeletal muscle cells after muscle overload and its contribution to the ensuing hypertrophic response. Myofibers in control muscles of wild type mic...

PROGRAM 9.30 R Dall’Aglio, Parma, Italy: Muscle Cell: How to achieve muscular hypertrophy 10.00 M Sandri, Padova, Italy: The role of apoptosis or programmed cell death in exercise-induced muscle damage 10.30 S Salmons, Liverpool, UK: Preelectrostimulation improves tissue resistance to exercise-induced muscle damage 11.10 Discussion 11.50 U Carraro, Padova, Italy: The protocols of LD wrap stimul...

Compensatory hypertrophy was induced in the rat extensor digitorum longus muscle by extirpation of the synergistic tibialis anterior. Injections of 3H-thymidine (2 muCi/g body weight) was given at 24, 48, and 72 h after the operation. In animals killed immediately after the last injection both satellite cell nuclei and true muscle nuclei were labeled, whereas in animals killed 4 weeks later onl...

A 47-year-old white male with a background history of chronic left sciatic pain developed a lump on the left thigh. Muscle MRI showed changes consistent with myotome L5 hypertrophy, while a lumbosacral MRI showed a disc protrusion at L4-L5. Continuous complex repetitive discharges became evident through needle electromyogram with a muscle biopsy showing chronic denervation changes. Botulinum to...

Investigation of volitional animal models of resistance training has been instrumental in our understanding of adaptive training. However, these studies have lacked reactive force measurements, a precise performance measure, and morphological analysis at a distinct phase of training - when initial strength gains precede muscle hypertrophy. Our aim was to expose rats to one month of training (70...

[Purpose] The purpose of this study was to examine whether a low intensity exercise using an eccentric contraction would result in skeletal muscle hypertrophy in rats. [Subjects and Methods] Eighteen female Wistar rats were used in this study. The rats were randomly divided into three groups. The control group performed no exercise. The level group ran on a treadmill on a 0° incline. The downhi...