Complement is an important mediator of the injuries observed after skeletal muscle ischemia and subsequent reperfusion. Although the classical pathway had been assumed to be the major pathway of activation leading to injury, the mannose-binding lectin (MBL) pathway might also play a contributing role. In this study, we found that MBL-deficient mice had significant protection after skeletal musc...

abstract introduction: cardiovascular fitness as the ability of the system - respiratory and skeletal muscle to achieve a certain level of activity is defined as, where after spinal cord injury can be reduced through exercise can increase this capacity. objective: the objective of this study, veterans with spinal cord injury spirometric indices in various athletic sports (archery, wheelchairran...

The authors of Muscle Imbalances – Fact or Fiction, have correctly identified the complexities of quantifying muscle imbalances as related to predisposition to injury. It seems intuitive that significant muscle imbalance would predispose one to injury during high performance sport or strenuous activities common with laborers in industrial settings. However, scientific evidence in support of thi...

Ischemia/reperfusion (IR) injury can induce skeletal muscle fibre death and subsequent regeneration. By 14 days, absolute and specific maximal forces and fatigue resistance in ischemic/reperfused soleus muscles were still reduced (-89%, -81%, and -75%, resp.) as compared to control muscles (P < .05). The decrease of these parameters in ischemic/reperfused muscle was much greater than that of my...

BACKGROUND Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed supraspinatus force and susceptibility to injury in the rat model of RTC tear, and compared these functional changes to histopathology of the muscle. METHODS Unilateral RTC tears wer...

[Purpose] We reported that carbon dioxide (CO2) water bathing accelerates skeletal muscle regeneration; however, the underlying mechanism was unclear. MyoD and myogenin play roles in muscle regeneration, and the purpose of this study was to determine changes in MyoD and myogenin caused by CO2 water bathing after injury. [Subjects] Sixteen female Wistar rats (n = 4 per group) were used. [Methods...

Past contraction-induced skeletal muscle injury reduces the degree of subsequent injury; this phenomenon is called the "repeated bout effect (RBE)." This study addresses the mechanisms underlying the RBE, focusing on primary calcium-dependent injury pathways. Wistar rats were subdivided into single injury (SI) and repeated injury (RI) groups. At age 10 weeks, the right gastrocnemius muscle in e...

Skeletal muscles can be injured by their own contractions, especially when the muscle is stretched during a lengthening contraction. Exposing a muscle to a conditioning protocol of stretches without activation (passive stretches) before lengthening contractions reduces contraction-induced injury. Although passive stretching does not damage muscle fibers, neutrophils are elevated in the muscle a...

The commonly used muscle injury grading systems based on three grades of injury, representing minor, moderate and complete injuries to the muscle, are lacking in diagnostic accuracy and provide limited prognostic information to the clinician. In recent years, there have been a number of proposals for alternative grading systems. While there is recent evidence regarding the prognostic features o...

[Purpose] The purpose of this study was to determine the baseline values knee joint extension muscle strength required for walking independence by patients with acute incomplete cervical cord injury. [Participants and Methods] Fifty-nine spinal injury ASIA Impairment Scale C D who were admitted an care hospital included study. classified into two groups, non-independence, their basic informatio...